Treating periodontal disease may improve metabolic control in diabetics

Vergnes, Jean-Noël

doi:10.1038/sj.ebd.6400734

Cited by 20 publications

(16 citation statements)

References 6 publications

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“…Oral health status has long been reported as an important determinant of morbidity and mortality in the general population (1,15,20,33,39,51,62,63,68,72,78,88,91,101,102,106,108). An eminent component of oral health is the number of remaining teeth, with tooth loss resulting in partial or complete edentulism as its consequence.…”

mentioning

confidence: 99%

Implant‐assisted complete prostheses

Emami¹,

Michaud²,

Sallaleh³

et al. 2014

Periodontology 2000

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The current review was undertaken to obtain a better understanding of the knowledge base of implant-assisted complete dental prostheses (fixed and removable) in the treatment of the completely edentulous maxilla or mandible. Indications, advantages and disadvantages, complications and maintenance issues, as well as the cost-effectiveness of both treatments, are discussed to help clinicians in their therapeutic decision-making. In summary, when indicated and depending on the patients' needs, both removable and fixed implant-assisted prostheses are highly safe, reliable and satisfactory treatment modalities for the rehabilitation of edentulous jaws. Careful and precise treatment planning is highly recommended to assist the clinician in preventing potential prosthetic failures. The review also reveals that there is still a need for data, generated using robust research methods, on some patient-based and clinical outcomes.

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mentioning

confidence: 99%

Implant‐assisted complete prostheses

Emami¹,

Michaud²,

Sallaleh³

et al. 2014

Periodontology 2000

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“…Local inflammation in patients with diabetes promotes a rise in blood glucose, worsening the metabolic state (Bender & Bender 2003), much like periodontal disease (Katz 2001). It suggests that when periodontal and periapical infections are treated, it may improve diabetic treatment aiming to support metabolic disease control (Rees 2000, Simpson et al 2010, Vergnes 2010. When untreated, these infections may foment metabolic alterations caused by increased overall insulin resistance promoted by the activation of inflammatory pathways (Segura-Egea et al 2012).…”

Section: Dm and Inflammatory Pulpal And Periapical Diseasementioning

confidence: 99%

Diabetes mellitus and inflammatory pulpal and periapical disease: a review

et al. 2013

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Diabetes mellitus (DM) is one of the most common metabolic disorders. DM is characterized by hyperglycaemia, resulting in wound healing difficulties and systemic and oral manifestations, which have a direct effect on dental pulp integrity. Experimental and clinical studies have demonstrated a higher prevalence of periapical lesions in patients with uncontrolled diabetes. The influence of DM on periapical bone resorption and its impact on dental intervention of such patients are reviewed, and its aetiology and pathogenesis are analysed at molecular level. Pulps from patients with diabetes have the tendency to present limited dental collateral circulation, impaired immune response, increased risk of acquiring pulp infection (especially anaerobic ones) or necrosis, besides toothache and occasional tendency towards pulp necrosis caused by ischaemia. In regard to molecular pathology, hyperglycaemia is a stimulus for bone resorption, inhibiting osteoblastic differentiation and reducing bone recovery. The relationship between poorly controlled diabetes and bone metabolism is not clearly understood. Molecular knowledge about pulp alterations in patients with diabetes could offer new therapeutic directions. Knowledge about how diabetes affects systemic and oral health has an enduring importance, because it may imply not only systemic complications but also a higher risk of oral diseases with a significant effect on pulp and periapical tissue.

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“…One prospective 5 year study of 2,973 nondiabetic individuals demonstrated that those with severe periodontitis had approximately a 5x greater absolute increase in HbA1c over the observation period when compared to nonperiodontitis patients. Also, some reviews and meta-analyses have identified reductions in HbA1c following periodontal therapy [14,15].…”

Section: Risk Factors Of Periodontitismentioning

confidence: 99%

Periodontitis- A Review

Shah¹

2017

Med Clin Rev

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The early form of periodontitis is gingivitis where inflammatory changes including bleeding and swelling are restricted to marginal gingiva and surrounding connective tissue, without the involvement of periodontal ligament. Periodontitis occurs when inflammatory changes reach the periodontal ligament and alveolar bone ultimately leading to tooth loss. The underlying cause of the disease is the presence of a polymicrobial biofilm that forms as plaque on the tooth surface and the resulting host response that this plaque induces. Inflammatory responses are initiated by a number of late stage colonizers and the virulence factors they produce. Among these late stage pathogens is P. gingivalis, a Gram negative, asacchrolytic bacterium with a large arsenal of virulence factors. P. gingivalis produces up to 13 virulence factors involved in host evasion and 21 virulence factors involved in tissue destruction. The presence of these virulence factors induces the production of proinflammatory chemokine and cytokine responses often seen in the saliva and gingival crevicular fluid of individuals with periodontitis.

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Treating periodontal disease may improve metabolic control in diabetics

Cited by 20 publications

References 6 publications

Implant‐assisted complete prostheses

Implant‐assisted complete prostheses

Diabetes mellitus and inflammatory pulpal and periapical disease: a review

Periodontitis- A Review

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