Treating Venous Thromboembolism Post Intracranial Hemorrhage: A Case Report

Abstract

Venous thromboembolism (VTE) is a significant issue occurring due to genetic, acquired and circumstantial risk factors. Treatment is according to the clinical situation and judgment for long term anticoagulation based on individual risk. Anticoagulation after a history of a hemorrhagic stroke poses a therapeutic dilemma. We present a case of a 68-year-old male who presented with right-sided chest pain and shortness of breath. Workup included a CT that was positive for multiple right-sided pulmonary emboli (PE). The patient has a past medical history of Factor V Leiden Mutation, recurrent PE, and deep vein thrombosis (DVT). Two months prior he was diagnosed with a 1.3-cm intracranial hemorrhage (ICH) from multiple cavernous angiomas. At that time his warfarin was discontinued and an inferior vena cave (IVC) filter was placed. Facing the recent ICH and now multiple and recurrent PE, it was decided to resume anticoagulation based on ICH location. ICH from a deep source is likely a better characteristic that favors a resumption of anticoagulation. Our case will highlight that IVC filters cannot be solely relied upon in patients that are at high risk for thrombotic events with underlying genetic thrombophilia.

Patients with venous thromboembolism after spontaneous intracerebral hemorrhage: a review

“…The available literature is almost exclusively case reports. Ajmeri et al [ 79 ] presented a case of a 68-year-old male who suffered from recent ICH and recurrent PE. The anticoagulation therapy was initiated with UFH after a CT scan was done to eliminate active bleeding, and then altered to enoxaparin.…”