Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain

Fornaro, Michele; Berardis, Domenico De; Iasevoli, Felice; Pistorio, Maria Luisa; D’Angelo, Emanuela; Mungo, S.; Martino, Matteo; Ventriglio, Antonio; Cattaneo, C; Favaretto, Ettore; Debbio, Alessandro Del; Romano, Anna; Ciampa, G.; Elassy, Mai; Perugi, Giulio; Pasquale, Concetta De

doi:10.1016/j.jad.2013.07.004

Cited by 41 publications

(25 citation statements)

References 52 publications

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“…However, in an earlier study carried out in a relative small cohort of patients suffering from different severe psychiatric disorders including BD patients, no significant difference in non-planning impulsivity subscore between patients with or without poor medication adherence was reported (Liraud and Verdoux, 2001). In a larger and recent study, performed in depressed BD type II patients, higher BIS total scores as well as all three domains subscores were demonstrated in non-adherent as compared to adherent patients (Fornaro et al, 2013) but it could not be exclude that mood symptoms influence also impulsivity (Stanford et al, 2009).…”

Section: Discussionmentioning

confidence: 84%

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Belzeaux¹,

Boyer²,

Mazzola-Pomietto³

et al. 2015

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 84%

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Belzeaux¹,

Boyer²,

Mazzola-Pomietto³

et al. 2015

Journal of Affective Disorders

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“…First-episode depression was shown to be relieved by prescription of antidepressants per se in 47.8% and mood stabilizers only in 8.7% of migraineurs with comorbid BD in our cohort. This seems notable given the increased likelihood of pain-killer medication abuse, poor treatment adherence, and poor therapeutic outcome and even an increased risk of suicidality in case of misdiagnosing bipolar characteristics in migraine–BD comorbidity 11,37–39…”

Section: Discussionmentioning

confidence: 99%

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Kıvılcım¹,

Altıntaş²,

Domaç³

et al. 2017

NDT

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PurposeThe aim of this study was to evaluate the prevalence of comorbid bipolar disorder (BD) among migraineurs and the impact of migraine–BD comorbidity on disease characteristics.Patients and methodsA total of 120 adult patients diagnosed with migraine at a single tertiary care center were included in this cross-sectional study. Data on sociodemographic and migraine-related characteristics, family history of psychiatric diseases, comorbid psychiatric diseases, and first-episode characteristics were recorded. Mood Disorders Diagnosis and Patient Registration Form (SCIP-TURK), Mood Disorder Questionnaire (MDQ), and Hypomania Checklist-32-Revised (HCL-32-R) were applied to all patients by experienced clinicians, and clinical diagnoses were confirmed using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Migraine Disability Assessment Scale (MIDAS) was used to evaluate the headache-related disability. Study parameters were compared between migraineurs with and without comorbid BD.ResultsThe diagnosis of comorbid BD was confirmed in 19.2% of migraineurs. A significantly higher percentage of patients with comorbid BD than those without comorbid BD had family history of BD (39.1% vs 6.2%, P<0.001), suicide attempt (30.4% vs 5.2%, P<0.001), and physical abuse (52.2% vs 26.8%, P=0.019). MIDAS scores were significantly higher (50.6 [43.2] vs 33.8 [42.7], P=0.0422) in migraineurs with comorbid BD than in those without comorbid BD. Multivariate logistic regression model revealed that a positive family history of type I BD (odds ratio [OR], 14.42; 95% confidence interval [CI], 2.94–70.73; P=0.001) and MIDAS scores >30 (OR, 3.69; 95% CI, 1.12–12.19; P=0.032) were associated with 14.42 times and 3.69 times increased likelihood of BD, respectively.ConclusionOur findings revealed comorbid BD in a remarkable percentage of migraineurs and a higher likelihood of having BD in case of a positive family history of type I BD and MIDAS scores >30. Comorbid BD was associated with a higher rate for a family history of BD, suicide attempt, and childhood physical abuse as well as aggravated migraine-related disability among migraineurs. Migraineurs with and without comorbid BD showed similar sociodemographic and migraine disease characteristics as well as similar high rates for comorbid anxiety and first-episode depression.

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“…Despite the need for the future assessment of the above specific features and/or special populations, as outlined by most of the reviewed systematic reviews and additional commentaries on the matter, overall evidence of efficacy of lurasidone as (acute antidepressant) monotherapy for adult patients with BD has an additional translational value [20, 21], as many individuals with BD are treated with polypharmacy even in circumstances where the most adequate initial approach would be monotherapy [17, 18], with potential detrimental effects on overall treatment adherence [99, 100]. …”

Section: Discussionmentioning

confidence: 99%

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

Fornaro

Berardis²,

Perna

et al. 2017

BioMed Research International

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Introduction A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic. Methods Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception until October 2016. Results Twelve included systematic reviews were of moderate-to-high quality and consistent in covering the handful of RCTs available to date, suggesting the promising efficacy, safety, and tolerability profile of lurasidone. Concordance on the drug profile seems to be corroborated by a steadily increasing number of convergent qualitative reports on the matter. Limitations Publication, sponsorship, language, citation, and measurement biases. Conclusions Despite being preliminary in nature, this overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall. As outlined by most of the reviewed evidence, recommendations for future research should include further controlled trials of extended duration.

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Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain

Cited by 41 publications

References 52 publications

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

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Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain

Cited by 41 publications

References 52 publications

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Screening for bipolar disorder among migraineurs: the impact of migraine&ndash;bipolar disorder comorbidity on disease characteristics

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

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Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics