Treatment and Developmental Therapeutics in Aspergillosis. 2. Azoles and Other Antifungal Drugs

Abstract

The present article surveys the anti-Aspergillus activity of various azole derivatives as well as a number of miscellaneous other antifungal agents. The drawbacks of sodium (potassium) iodide therapy in the management of pulmonary aspergilloma are discussed along with current efforts at treatment of allergic bronchopulmonary aspergillosis and Aspergillus-induced otomycosis.

Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients

“…The early azoles such as clotrimazole, miconazole, and ketoconazole were not effective enough to be relevant in the therapy of IA. The first triazole, fluconazole showed only in vitro activity against IA [110]. The further development of triazoles has led to compounds effective against Aspergillus spp.…”

Structure and Generation Mechanism of a Novel Degradation Product Formed by Oxidatively Induced Coupling of Miconazole Nitrate with Butylated Hydroxytoluene in a Topical Ointment Studied by HPLC-ESI-MS and Organic Synthesis

“…Miconazole nitrate (1), 1‐[2‐(2,4‐dichlorobenzyloxy)‐2‐(2,4‐dichlorophenyl) ethyl] imidazolium nitrate, is an imidazole antifungal agent that has shown fungistatic activity against a number of pathogenic fungi and yeasts 1–10. 1 can be administered by intravenous infusion in the treatment of severe systemic fungal infections including candidiasis, coccidioidomycosis, cryptococcosis, paracoccidioidomycosis, and infections due to Pseudallescheria boydii.…”