Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency Experience

Truong, Pauline T.; Jones, Stuart; Martens, Benjamin; Alexander, Cheryl; Paquette, M.; Joe, Harry; Hart, Janace; Allan, Sharon J.

doi:10.1245/s10434-009-0734-8

Cited by 88 publications

(84 citation statements)

References 21 publications

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“…The predominance of angiosarcoma was also reported previously by researchers in Italy (28.6%), 18 the Mayo Clinic (41%), 19 and the British Columbia Registry. 20 In contradistinction, a single study from Germany reported the predominance of undifferentiated sarcoma, 20 which may suggest either regional variances in histological distribution or differences in histological classifications across the eras. Whereas we found no sex predilection for cardiac sarcomas, we note low use of surgery (43.6%), and radiation (19.1%).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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Background-The aim of this study was to investigate the incidence, histopathology, demographics, and survival associated with primary malignant cardiac tumors (PMCTs). Methods and Results-We queried the Surveillance, Epidemiology and End Results (SEER) 18 registry from the National Cancer Institute for all PMCTs diagnosed from 1973 to 2011. We describe PMCT histopathology and incidence, comparing characteristics and survival of these patients with those of patients with extracardiac malignancies of similar histopathology. From a total of 7 384 580 cases of cancer registered in SEER, we identified 551 PMCTs (0.008%). The incidence of PMCT diagnosis is 34 cases per 100 million persons and has increased over time (25.1 in 1973-1989, 30.2 in 1990-1999, and 46.6 in 2000-2011). Most patients are female (54.1%) and white (78.6%) with median age at diagnosis of 50 years. The most common PMCTs are sarcomas (n=357, 64.8%), followed by lymphomas (n=150, 27%) and mesotheliomas (n=44, 8%). Most patients are diagnosed with tissue sample (96.8%). Although use of chemotherapy is not documented in SEER, 19% of patients received radiation and 44% had surgery. After a median follow-up of 80 months, 413 patients had died. The 1-, 3-, and 5-year survival rates were 46%, 22%, and 17% and have improved over the eras, with 1-, 3-, and 5-year survival rates of 32%, 17%, and 14% for 1973 to 1989 and 50%, 24%, and 19% for 2000 to 2011 (P=0.009). Cardiac sarcomas and mesotheliomas are the most lethal PMCTs, with 1-, 3-, 5-year survival rates of 47%, 16%, and 11% and of 51%, 26%, and 23% compared with 59%, 41%, and 34% for lymphomas, respectively (log rank test P<0.001). Patients with cardiac lymphomas and sarcomas are younger and have worse survival than patients with extracardiac disease of similar histopathology (P<0.001). Conclusions-PMCTs are extremely rare and continue to be associated with poor prognosis. Over the past 5 decades, the incidence and survival of patients diagnosed with PMCT appear to have increased.

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Section: Discussionmentioning

confidence: 99%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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“…42 A complete surgical excision when possible should be performed and has shown an advantage in overall survival. 15,17,18,37,40,[43][44][45] Unfortunately, because of the extent of local spread and yComparison of all subtypes. 8Other includes: high-grade sarcoma (n = 2), pleomorphic sarcoma of unspecified type (n = 1), high-grade spindle cell sarcoma (n = 3), low-grade spindle cell sarcoma (n = 1), spindle cell sarcoma (n = 2).…”

Section: Discussionmentioning

confidence: 99%

“…35 However, there was an improvement in the number of patients surviving beyond 3 years compared with reports of former studies. 4,5,[16][17][18] The estimated 1-, 2-, and 3-year survival rates for the cohort as a whole are given in Table 4.…”

Section: Survival Outcomementioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14] Malignant cardiac tumors have a poor prognosis with overall median survival ranging from 6 months to a few years. 5,[15][16][17][18][19][20] The most common symptom at presentation is dyspnea, whereas the complete spectrum includes but is not limited to cardiac symptoms (chest pain, syncope, pericardial effusions, valvular dysfunction, arrhythmias, congestive heart failure, thromboembolic disease, sudden cardiac death) and systemic symptoms of underlying malignant disease (eg, fatigue, fever, weight loss). 21,22 The tumor at times may not produce any symptoms and is established as an incidental finding.…”

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confidence: 99%

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Primary Cardiac Sarcoma

Randhawa

Budd²,

Randhawa³

et al. 2016

American Journal of Clinical Oncology

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“…However, Truong et al reported that patients treated with complete resection had improved overall survival compared with those with incompletely resected disease (25 months vs. 6 months, p=0.042) (10). The high rates of disease progression and mortality highlight the need for more effective local and systemic treatments that may be used in conjunction with surgery to improve patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

Primary Cardiac Angiosarcoma of the Right Auricle with Difficult-to-Treat Bilateral Pleural Effusion

et al. 2011

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A 70-year-old woman was admitted to our hospital with pleuritis and pericarditis. Cytological examination of pleural and pericardial effusion, and pleural biopsy specimens under thoracoscopy revealed no specific pathological findings. The pleural effusion was drained continuously; however, she died of circulatory insufficiency at day 45 from admission. At autopsy, a fragile hemorrhagic mass arising from the right auricle had invaded bilateral pleura and the pericardium directly without distant metastasis. Immunohistochemical staining showed that the tumor cells expressed endothelial markers such as CD31 and CD34 antibodies, and factor VIII-related protein. These findings supported the diagnosis of a poorly differentiated angiosarcoma.

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Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency Experience

Cited by 88 publications

References 21 publications

Characteristics and Survival of Malignant Cardiac Tumors

Characteristics and Survival of Malignant Cardiac Tumors

Primary Cardiac Sarcoma

Primary Cardiac Angiosarcoma of the Right Auricle with Difficult-to-Treat Bilateral Pleural Effusion

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