Treatment and prognosis of oral mucosal melanoma

Sun, Chuan Zheng; Chen, Yan Feng; Jiang, Yu; Hu, Ze Dong; Yang, An Kui; Song, Ming

doi:10.1016/j.oraloncology.2012.01.019

Cited by 34 publications

(34 citation statements)

References 20 publications

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“…Treatment for these lesions involves complete excision with adequate negative margins; nodal dissection should also be performed. (9) Unfortunately, these tumors tend to spread radially to mucosal tissue and lymph nodes. Surgical neck dissection is indicated for lymph node metastasis in the neck region.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mucosal Melanoma of the Maxillary Sinus

Modabbernia¹,

Bagheri²,

Bashardoust³

2017

3dj

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Section: Discussionmentioning

confidence: 99%

Malignant Mucosal Melanoma of the Maxillary Sinus

Modabbernia¹,

Bagheri²,

Bashardoust³

2017

3dj

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“…Although there is a slight male preponderance (1.2:1), 1,4 some studies have been reported higher gender distribution of mucosal melanoma for women, 5,6 other indicate that there is no significant difference between sexes in the incidence of this tumor.…”

mentioning

confidence: 94%

“…2 Primary oral mucosal melanoma (POMM) is excessively uncommon in prepubertal children. 3 Although there is a slight male preponderance (1.2:1), 1,4 some studies have been reported higher gender distribution of mucosal melanoma for women, 5,6 other indicate that there is no significant difference between sexes in the incidence of this tumor. 2,7 The incidence rate of POMM is highest among Asian men.…”

mentioning

confidence: 98%

Melanoma of the oral cavity: pathogenesis, dermoscopy, clinical features, staging and management

Warszawik-Hendzel

Słowińska²,

Olszewska

et al. 2014

J Dermatol Case Rep

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Primary mucosal melanoma of the oral cavity is an exceedingly rare neoplasm which is estimated to comprise 1-2% of all oral malignancies. In contrast to cutaneous melanomas, the risk factors and pathogenesis are poorly understood. The predominate localization of primary oral melanoma is hard palate and maxillary alveolus. Dermoscopy may be utilized as an adjunctive tool in the clinical differential diagnosis of oral mucosal melanoma whenever the lesion is accessible with a dermoscope. Surgery is the mainstay of treatment, but it may be challenging depending on the location of the tumor within the oral cavity and its size. Adjuvant therapy with dacarbazine, platinum analogs, nitrosoureas and interleukin-2 have been utilized with low response rates. Imatinib may be effective for patients with with c-Kit gene mutations. Sunitinib and dasatinib have been reported effective in selected cases. Vemurafenib and dabrafenib are targeted agents for patients with BRAF mutation-positive melanoma. Ipilimumab, an anti-cytotoxic T-lymphocyte antigen 4 antibody and pembrolizumab, a monoclonal antibody targeting programmed death 1 receptor may be a feasible treatment option in patients with metastatic mucosal melanoma. (J Dermatol Case Rep. 2014; 8(3) Melanoma is a malignant tumor that arises from melanocytes and is most commonly cutaneous in origin. Extracutaneous melanomas are known to be exceedingly rare and aggressive neoplasms that embrace ocular, mucosal and leptomeningeal melanomas. EpidemiologyMucosal melanomas are estimated to comprise 4-6.8 % of all primary melanomas. 1The incidence rate for mucosal melanoma (MM) is 2.3 per million. 1,2The incidence of MM increases with age. Older patients have tenfold higher incidence of MM compared to patients under the age of 60 years. 2Primary oral mucosal melanoma (POMM) is excessively uncommon in prepubertal children. 3Although there is a slight male preponderance (1.2:1), 1,4 some studies have been reported higher gender distribution of mucosal melanoma for women, 5,6 other indicate that there is no significant difference between sexes in the incidence of this tumor. 2,7The incidence rate of POMM is highest among Asian men. 3,6 Among the Japanese oral melanoma accounts for 7.5 % of all melanomas versus less than 1 % in Caucasians. 8,9Pathogenesis In contrast to cutaneous melanomas, the etiology and pathogenesis of POMM is poorly understood and no etiological and intraoral risk factors, other than preexisting pigmented nevi, have been identified. 10,11 POMM are believed to arise from pigmented nevi, pre-existing pigmented areas or de novo (30% cases) from apparently normal mucosa. 9,12 Although Kahn et al 13 described transformation of a benign oral pigmentation to primary oral melanoma, a definite precursor lesion has not been identified. 14,15 In the oral cavity, mechanical trauma including injury from ill-fitting prostheses, infection, tobacco use has been cited as possible causative factors, but its etiological role seems unlikely. 30Amelanotic oral melanoma is partic...

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“…OMMs metastasize to regional lymph nodes early in the course of the disease and spread to distant sites by haematogenous dissemination, usually to lungs, bone, liver, brain and skin. [2][3][4] The prognosis is poor with a reported 5-year survival rate of 15-20%. 5,6 Although the pathogenesis remains largely unknown, malignant transformation of melanocytes occurs through the sequential accumulation of an unknown number of genetic and molecular alterations.…”

Section: Introductionmentioning

confidence: 99%

Oral mucosal melanoma

Khammissa

Altini

Meer

et al. 2017

Translational Research in Oral Oncology

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Background: Oral mucosal melanoma (OMM) is relatively rare, runs an aggressive course, affects most frequently the hard palate and the maxillary gingiva, and may be multifocal. The aetiological factors and the chain of molecular events that give rise to OMM and to its growth and metastasis are largely unknown. Objectives: The purpose of this retrospective study was to characterize some clinical and histopathological features of OMM in a South African sample.

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Treatment and prognosis of oral mucosal melanoma

Cited by 34 publications

References 20 publications

Malignant Mucosal Melanoma of the Maxillary Sinus

Malignant Mucosal Melanoma of the Maxillary Sinus

Melanoma of the oral cavity: pathogenesis, dermoscopy, clinical features, staging and management

Oral mucosal melanoma

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