Treatment and Survival Outcome for Molecular Breast Cancer Subtypes in Black Women

Abstract

The basal cell-like subtype is associated with a worse prognosis, a higher incidence of distant metastasis, and may be more prone to local recurrence when managed with breast-conserving therapy.

Survival Time and Molecular Subtypes of Breast Cancer after Radiotherapy in Thailand

“…This is consistent with the findings of a study of AfricanAmerican women with breast cancer (Ihemelandu et al, 2008), which reported that patients with stage III and IV cancers had a higher risk of death than patients with stage I and II malignancies (HR=2.33, 95%CI: 1.11-44.89).…”

“…The Italian study reported that the survival of breast cancer patients with triple negative and HER2-enriched had lower survival rates than patients with other molecular subtypes (Minicozzi et al, 2013). Our findings are also supported by a study of breast cancer in black women, which found that triple negative and HER2-enriched patients had the lowest survival 5-year survival rates (Ihemelandu et al, 2008). Our findings and those of others indicate that different molecular subtypes are associated with different survival rates and that the rates are likely to be lowest in breast cancer patients with triple negative and HER2-enriched molecular subtypes.…”

Breast Cancer Subtypes Identified by the ER, PR and HER-2 Status in Thai Women

“…The breast cancer subtypes related to various clinical outcomes, including overall survival (Ihemelandu et al, 2008;Sorlie et al, 2001). Luminal subtypes demonstrated better clinical outcomes than basal like and HER-2 subtypes (Sorlie et al, 2001;Sotiriou et al, 2003).…”

“…Based on genetic profiles, invasive ductal carcinoma (IDC) is classified into different 5 molecular subtypes: luminal-A, luminal-B, HER-2, basal and normal-breast like subtypes (Sorlie et al, 2001;Sorlie et al, 2003). Different subtypes may have different presenting features, different locoregional relapse, and different prognosis (Ihemelandu et al, 2008;Nguyen et al, 2008;Voduc et al, 2010;Wiechmann et al, 2009). Basal-like and HER-2 subtypes were associated with aggressive clinical behaviors and poor survival outcome.…”

A Targetable Androgen Receptor–Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers

“…18 Interestingly, however, mortality for patients with basal-like breast cancer (BLBC) has been reported as being higher among white patients (hazard ratio, 2.0; 95% confidence interval, 1.2-3.4) than African American patients (hazard ratio, 1.5; 95% confidence interval, 1.0-2.4) in some studies, 19,20 whereas others have noted higher mortality for African Americans even after adjusting for treatment and comorbidities. 20 Other studies have also noted a higher frequency of basal-like carcinomas among young African Americans 6,[19][20][21][22] and younger women in Africa 23,24 compared with European American, European, and Asian women. 20,[25][26][27][28][29] Aside from being younger, women with TNBC have both modifiable and nonmodifiable risk factors that include earlier age at menarche and at first pregnancy, increased parity, decreased breast-feeding, higher body mass index, and lower socioeconomic status, based on multiple population-based studies.…”