Treatment approaches for urachal cancer: Use of immunotherapy and targeted therapies

Benjamin, D. Paul; Kalebasty, Arash Rezazadeh

doi:10.1177/20363613231189984

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Although there is no standardized protocol for urachal cancer, its treatment usually involves surgery and additional chemotherapy in some cases. Regiments 5-fluorouracil (5-FU) and FOLFOX (5-FU, oxaliplatin, and leucovorin) have both been described as effective in urachal cancer cases, which makes sense considering the similar profile of urachal cancer to CRC [10,18]. Indeed, next-generation sequencing studies have revealed that urachal cancer has a genomic profile that closely resembles that of CRC [18].…”

Section: Discussionmentioning

confidence: 99%

“…Regiments 5-fluorouracil (5-FU) and FOLFOX (5-FU, oxaliplatin, and leucovorin) have both been described as effective in urachal cancer cases, which makes sense considering the similar profile of urachal cancer to CRC [10,18]. Indeed, next-generation sequencing studies have revealed that urachal cancer has a genomic profile that closely resembles that of CRC [18]. This could be interesting because as previously discussed, CRC seems to be one of the cancers that is at increased risk in Crohn's disease patients.…”

Section: Discussionmentioning

confidence: 99%

“…This could be interesting because as previously discussed, CRC seems to be one of the cancers that is at increased risk in Crohn's disease patients. This potential link could have both meaning for risk assessment and follow-up of Crohn's disease patients but also as therapeutic options for urachal cancer [18].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple Complications of Crohn’s Disease and the Need for Early and Continuous Multidisciplinary Undertaking

Dogahe,

Taghavi,

Cubilier

et al. 2023

J Med Cases

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Crohn's disease is an inflammatory disease that typically affects the bowels but can also have many different extraintestinal manifestations. One of those complications is immunoglobulin A nephropathy (IgAN), which is one of the most encountered renal lesions in the setting of Crohn's disease. Another point of focus for Crohn's patients is the risk of cancer, with a higher risk of colorectal cancer but also extraintestinal neoplasia such as hepatobiliary, hematological, and urinary tract neoplasia. We present the case of a young patient suffering from long-term Crohn's disease and subsequent IgAN leading to end-stage kidney disease and hemodialysis. The patient was diagnosed young and had undergone multiple surgeries and different treatments in various countries. He then presented in our center already with advanced chronic renal failure from IgAN that was unknown due to poor multidisciplinary follow-up. Shortly after starting hemodialysis, he developed a large abdominal mass, first thought to result from Crohn's-related fistula. This mass turned out to be a urachal adenocarcinoma, a rare type of bladder cancer with an especially poor prognosis. It is not known whether this type of cancer is associated with either Crohn's disease or IgAN, and no such association has been previously described. The treatment of urachal cancer usually relies on surgery, with the addition of chemotherapy in some cases. Unfortunately for our patient, his case was already so advanced at the moment of diagnosis that he was excluded from curative treatment and quickly passed away thereafter. This case illustrates many important aspects of the rigorous follow-up that is needed for Crohn's patients, with regular checkups, screening investigations, and the need for multidisciplinary evaluation. Furthermore, it describes the development of a rare type of cancer in the setting of Crohn's disease and IgAN, with no prior established link between these different pathologies.

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Section: Discussionmentioning

confidence: 99%