2010
DOI: 10.1002/ibd.21205
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Treatment-associated acute myeloid leukemia in a patient with Crohnʼs disease on 6-mercaptopurine

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Cited by 7 publications
(5 citation statements)
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“…A relationship between inflammatory bowel diseases (UC and Crohn’s disease) and leukemia may result from thiopurine treatment [10]. Azathioprine, an immune suppressant, has been classified as a carcinogen for non-Hodgkin lymphoma and skin cancer [11].…”
Section: Discussionmentioning
confidence: 99%
“…A relationship between inflammatory bowel diseases (UC and Crohn’s disease) and leukemia may result from thiopurine treatment [10]. Azathioprine, an immune suppressant, has been classified as a carcinogen for non-Hodgkin lymphoma and skin cancer [11].…”
Section: Discussionmentioning
confidence: 99%
“…50 Fabry et al observed 5 AML cases among 400 ulcerative colitis patients treated over an 8-year period. This was followed by a number of case reports and case series that suggested an association between inflammatory bowel disease and hematologic malignancies, in particular Crohn's disease to lymphoma and ulcerative colitis to leukemia, [51][52][53][54][55][56][57][58][59] as summarized in Table 2. There are 18 case reports of AML developing in patients with inflammatory bowel diseases.…”
Section: The Association Between Inflammatory Bowel Diseases and Myelmentioning
confidence: 99%
“…Of the four reported cases of t-AML/MDS secondary to AZA in inflammatory bowel disease (summarised in table 1), not one case had been exposed to immunosuppressive therapy aside from prednisolone 10–13. Although in three cases of 6-MP-related AML/MDS, there had been prior use of anti-tumour necrosis factor therapy 14 15…”
Section: Discussionmentioning
confidence: 99%
“…However, the less well-recognised complication of t-MDS–AML has been reported in a small number of IBD patients treated with azathioprine10–13 or 6-MP 14 15 24. These cases display characteristic cytogenetic hallmarks indicative of t-MDS–AML.…”
Section: Discussionmentioning
confidence: 99%