Treatment Attitudes for Belgian Women With Persistent Trichomonas vaginalis Infection in the VlaResT Study

Donders, Gilbert; Ruban, Kateryna; Depuydt, Christophe; Bellen, Gert; Broeck, Davy Vanden; Jonckheere, Jef; Jacquemyn, Yves

doi:10.1093/cid/ciy736

Cited by 2 publications

(2 citation statements)

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“…Candida albicans is an opportunistic pathogen that usually does not cause disease on the vaginal mucosa but may cause disease when the body’s immunity is reduced or the vaginal acidic environment changes [42]. TV is a contagious parasitic disease mainly transmitted through sexual intercourse [43]. Whether the natural history of HPV infection is affected by VVC or TV infection has not been fully investigated.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Liang

Chen

Qin

et al. 2019

Infect Agents Cancer

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Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women’s cervical health. This meta-analysis aimed to analyze the effects of vaginal microecology on Human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN). PubMed and Web of Science were systematically searched for eligible publications from January 2000 to December 2017. Articles were selected on the basis of specific inclusion and exclusion criteria. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS). Odds ratios (ORs) with a 95% confidence interval (95% CI) were calculated. Thirteen eligible studies were selected to evaluate the association of vaginal microecology with HPV infection and CIN. The factors related to HPV infection were bacterial vaginosis (BV) (OR 2.57, 95% CI 1.78–3.71, P<0.05), Candida albicans (VVC) (OR 0.63, 95% CI 0.49–0.82, P < 0.05), Chlamydia trachomatis (CT) (OR 3.16, 95% CI 2.55–3.90, P < 0.05), and Ureaplasma urealyticum (UU) (OR 1.35, 95% CI 1.20–1.51, P < 0.05). BV was also related to CIN (OR 1.56, 95% CI 1.21–2.00, P < 0.05). This meta-analysis of available literature suggested an intimate association of vaginal microecology and HPV infection with CIN. BV, CT and UU were associated to increased HPV infection, VVC was associated to decreased HPV infection, Lactobacillus is not associated to increased HPV infection, BV was associated to increased CIN development risk. Further large-scale studies are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Liang

Chen

Qin

et al. 2019

Infect Agents Cancer

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“…Our data revealed that 68.6% patients with trichomoniasis were not treated. A recent study in Belgium demonstrated that 58.1% of women repeatedly positive for T. vaginalis infection had received no treatment; this was attributed to low awareness, poor attention, and failure of contact tracing of physicians [43].…”

Section: Discussionmentioning

confidence: 99%

Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study

et al. 2019

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BackgroundTrichomonas vaginalis is a protozoan parasite that causes trichomoniasis and annually infects approximately 276 million people worldwide. We observed an ambiguously higher probability of trichomoniasis in patients from the psychiatric department of Tri-Service General Hospital. Herein, we aimed to investigate the association between trichomoniasis and the risk of developing psychiatric disorders.MethodsThe nationwide population-based study utilized the database of the National Health Insurance (NHI) programme in Taiwan. A total of 46,865 subjects were enrolled in this study from 2000–2013, comprising 9373 study subjects with trichomoniasis and 37,492 subjects without trichomoniasis as the control group. Cox proportional hazards regression analysis was performed to calculate the hazard ratio (HR) of psychiatric disorders during the 14 years of follow-up.ResultsOf the study subjects with trichomoniasis, 875 (9.34%) developed psychiatric disorders compared with 1988 (5.30%) in the control group (P < 0.001). The adjusted hazard ratio (aHR) of overall psychiatric disorders in the study subjects was 1.644 (95% confidence interval, CI: 1.514–1.766; P < 0.001). More specifically, the study subjects had a higher risk for developing an individual psychiatric disorder, including depression, anxiety, bipolar disorder, schizophrenia and substance abuse. Although metronidazole treatment reduced the risk for developing several subgroups of psychiatric disorders, significant reduction was detected for depression only. Furthermore, refractory trichomoniasis (trichomoniasis visits ≥ 2) enhanced the risk of psychiatric disorders.ConclusionsWe show herein that T. vaginalis infection increases the overall risk for psychiatric disorders. The novel role of T. vaginalis in developing psychiatric disorders deserves more attention, and the control of such a neglected pathogen is of urgent public health importance.Electronic supplementary materialThe online version of this article (10.1186/s13071-019-3350-x) contains supplementary material, which is available to authorized users.

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Treatment Attitudes for Belgian Women With Persistent Trichomonas vaginalis Infection in the VlaResT Study

Cited by 2 publications

References 30 publications

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study

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