Treatment decisions and usage of clotting factor concentrate by a cohort of Indian haemophilia patients

Dharmarajan, Sumedha; Gund, Pooja; Phadnis, Supriya; Lohade, Sunil; Lalwani, Anil K.; Kar, Anita

doi:10.1111/j.1365-2516.2011.02668.x

Cited by 11 publications

(15 citation statements)

References 6 publications

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“…Recently, single nucleotide polymorphisms (SNPs) in the encoding genes of bone remodeling agents (RANK/RANKL/OPG) have been reported in association with bone diseases such as low bone mineral density (BMD), Paget's disease, and osteoporosis [10,11,12,13]. SNPs may affect the gene expression or function of proteins [14].…”

Section: Introductionmentioning

confidence: 99%

“…On the basis of the bone resorption seen in bone diseases (e.g., osteoporosis) and periodontitis/peri-implantitis, and the relationship between the RANK gene polymorphisms and bone resorption [10,11,12,13], we supposed that the RANK SNP is a genetic determinant for periodontitis and peri-implantitis in some populations. The purpose of the present study was to evaluate the relationship between two functional known SNPs of the RANK gene in chronic periodontitis and peri-implantitis in an Iranian population.…”

Section: Introductionmentioning

confidence: 99%

“…The purpose of the present study was to evaluate the relationship between two functional known SNPs of the RANK gene in chronic periodontitis and peri-implantitis in an Iranian population. We analyzed rs3018362 and rs35211496 due to their significant effects on bone resorption in Paget's disease and osteoporosis [10,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

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Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Kadkhodazadeh

Baghani

Ebadian³

et al. 2014

J Periodontal Implant Sci

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PurposePeri-implantitis and periodontitis are inflammatory and infectious diseases of implant and tooth-supporting tissues. Recently, the role of gene polymorphisms of immune response components in the relevant pathogenesis has been investigated. The present study was the first to evaluate the relationship between two known single nucleotide polymorphisms (SNPs) of the receptor activator of nuclear factor kappa-β (RANK) gene (rs3018362 and rs35211496) in chronic periodontitis and peri-implantitis patients in an Iranian population.MethodsEighty-one periodontally healthy patients, 38 patients with peri-implantitis, and 74 patients with chronic periodontitis were enrolled in this study. DNA was extracted from blood arm vein samples by using Miller's salting out technique according to the manufacturer's instructions given in the extraction kit. The concentration of DNA samples was measured using a spectrophotometer. The genetic polymorphisms of the RANK gene were evaluated using a competitive allele specific polymerase chain reaction (KBioscience allele specific PCR) technique. Differences in the frequencies of genotypes and alleles in the diseased and healthy groups were analyzed using chi-squared statistical tests (P<0.05).ResultsAnalysis of rs35211496 revealed statistically significant differences in the expression of the TT, TC, and CC genotypes among the three groups (P=0.00). No statistically significant difference was detected in this respect between the control group and the chronic periodontitis group. The expression of the GG, GA, and AA genotypes and allele frequencies (rs3018362) showed no statistically significant difference among the three groups (P=0.21).ConclusionsThe results of this study indicate that the CC genotype of the rs35211496 RANK gene polymorphism was significantly associated with peri-implantitis and may be considered a genetic determinant for peri-implantitis, but this needs to be confirmed by further studies in other populations.Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Kadkhodazadeh

Baghani

Ebadian³

et al. 2014

J Periodontal Implant Sci

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“…Although the low usage of clotting factor concentrate in LICs and LMICs is widely known, primary data on OOP expenditure by households, and the consequence of economic limitations on the decision to treat have not been reported. Estimating OOP expenditure is methodologically challenging in developing countries due to lack of completeness of hospital records, as patients may not seek treatment due to affordability issues [11]. In developed countries, hospital records provide accurate treatment data and can be used for studies on haemophilia economics [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Out‐of‐pocket and catastrophic expenditure on treatment of haemophilia by Indian families

et al. 2013

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In low-income countries, haemophilia treatment is not supported by national health services. Data on the burden of out-of-pocket (OOP) expenditure on households are unavailable from these countries. This study measured the OOP expenditure on treatment of haemophilia by Indian households. We used 20 weeks of follow-up data of 24 haemophilia A patients to estimate the annual bleeding rate for each patient and the actual OOP expenditure on treatment. We used this observational data to calculate the annual OOP expenditure on treatment if all bleeding episodes were to be treated with clotting factor concentrate. Using previously published methodology, we estimated if the expenditure was catastrophic to households or not. The observed monthly expenditure on treatment ranged from 1.5% to 12% of monthly income as not all bleeding episodes were treated with clotting factor concentrate. The estimated monthly expenditure if all bleeding episodes occurring over 1 year were to be treated would range from 21 to 314 times the monthly income of families. Nearly 68% of households would have experienced catastrophic expenditure. Treatment for haemophilia results in significant OOP expenditure for households, which is avoided by not providing standard treatment to patients. There is a need to mobilize prevention and care services for haemophilia in India and other low-income countries to mitigate the suffering due to lack of affordable treatment.

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“…8 A prospective study has reported that children with hemophilia, on an average have lost 0 to 50 days of school days due to bleeding. 9 Haemophiliacs, when compared to their classmates, tend to have more teacher-rated emotional, but not more behavioral disturbances, because of the impact of the chronic disorder on the child. The haemophilic child is greatly frustrated because of restrictions.…”

Section: Introductionmentioning

confidence: 99%

Impact of hemophilia on quality of life of affected children and their parents, a hospital based cross sectional study

Manikandasamy

Arumugasamy

Mathevan

2017

Int J Contemp Pediatr

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Background: Hemophilia can have a huge negative impact not only on the physical health but also on the psychological, economic and social well-being of the affected children and their family. Documentation of this negative impact on quality of life is vital in drawing the attention of relevant stakeholders to design and implement appropriate interventions.Methods: This was a cross sectional study, Children with hemophilia aged 4 to 12 years, and their parents who were attending the Pediatric Hematology Clinic of the Advanced Pediatric Centre, PGIMER, Chandigarh, between July 2009 and June 2010 were included in the study. The Hemo-QoL questionnaire was used to assess the quality of life after translation into local language and validation.Results: The study included 51 children with 10 children in 4-7 years age group and 41 children in 8-12 years age group and their parents. Perceived impact on family (77.3±14.7), poor physical health (62.9±29.8), sports and school (53.8±22.8) had the highest negative impact on QoL. Support from friends, family, and other persons seemed to have contributed positively towards the quality of life. Parents of older children had higher mean subscale scores in View of yourself subscale as compared to parents of younger children (40.8±14.2 vs 23.7±33.0, p value 0.018). Under Sports and school subscale also similar pattern was observed (48.2±20.7 Vs 34.1±13.8, P value 0.045).Conclusions: The Quality of life was poor both among children affected with hemophilia and their parents. Perceived impact on family, poor physical health and inability to participate in school/sports activities are the major contributors to poor QoL. Support from family, friends, and others is vital in maintaining QoL. The QOL worsens with increasing age of the child in both children and their parents.

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Treatment decisions and usage of clotting factor concentrate by a cohort of Indian haemophilia patients

Cited by 11 publications

References 6 publications

Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Out‐of‐pocket and catastrophic expenditure on treatment of haemophilia by Indian families

Impact of hemophilia on quality of life of affected children and their parents, a hospital based cross sectional study

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