Treatment decisions in T3N0M0 glottic carcinoma

Management of T3N0M0 Glottic Carcinoma: Therapeutic Outcomes

“…Twenty‐five percent of these patients was node‐positive. Bryant 4 reported no significant difference in 5‐year recurrence‐free survival in patients treated with RT alone and with those treated with TL, TL/RT, or both. Our study indicated that overall local and regional control was 74%.…”

“…Local recurrence after treatment of patients with T3N0 glottic cancer with radiation therapy (RT) has been reported to be between 49% and 67%. 2–4 Lundgren 5 reported increased local recurrence after treatment with RT in patients who had involvement of all three laryngeal regions and in patients with initial tracheostomy. Bryant 4 reported a local recurrence rate of 46% in patients treated with total laryngectomy (TL) or total laryngectomy and radiation therapy (TL/RT).…”

“… 2–4 Lundgren 5 reported increased local recurrence after treatment with RT in patients who had involvement of all three laryngeal regions and in patients with initial tracheostomy. Bryant 4 reported a local recurrence rate of 46% in patients treated with total laryngectomy (TL) or total laryngectomy and radiation therapy (TL/RT). Mendenhall 6 reported no significant difference in local and regional control in a series of patients with T3 glottic cancer treated with either RT or TL/RT.…”

Evidence and evidence gaps of laryngeal cancer surgery

“…For patients after total laryngectomy or adjuvant radio(chemo)therapy of T3 tumors, local control rates of 69–87% and 5-year survival rates of 53-86% were reported [136], [137], [138]. Already in 1991, it could be shown that patients with T4a carcinomas benefit from total laryngectomy because they respond more badly to a primarily non-surgical treatment concept and have a poorer survival rate than patients who underwent primary surgery [130].…”

Functional organ preservation in laryngeal and hypopharyngeal cancer

“…In those patients the local control rates average between 73% and 83% after partial laryngectomy [88], [89], [90], [91]. Patients treated with primary laryngectomy and bilateral neck dissection with or without adjuvant radiotherapy reached local control rates of 69%–87%, 5-year overall survival rates of 53%–56%, and a disease-specific survival rate of 71%–78% [92], [93], [94]. …”