Background: Facial fractures are a common presentation to hospitals worldwide. However, many uncertainties remain. The relevance of delay from injury to treatment is commonly disputed amongst surgeons and in the literature. Immediate or very early treatment is suggested by its advocates to improve treatment outcomes and the patient experience. However, there are many reasons why delay may be practical, unavoidable, or even clinically beneficial. Further, the deleterious effects of patient noncompliance, a classic confounding variable in the assessment of treatment delay, are frequently infection, malocclusion, trismus, nerve damage, fracture non-union, return to theatre, and radiographic outcome. Nineteen additional variables were included in the analysis to adjust for potential confounding. Study 3. Undertaken simultaneously and with the same patient cohort as study 2, a prospective case series analysing the effects of patient demographics on patient compliance. Demographics were measured with the following variables for each patient: age, gender, distance to oral and maxillofacial service, dental status, alcohol use, cigarette use, illicit drug use, employment status, and injury aetiology. Compliance with post-operative instructions was measured with the following variables for each patient: soft diet, mouthwash, oral antibiotics, cigarette cessation, and review appointment attendance. Study 4. Undertaken simultaneously and with the same patient cohort as studies 2 and 3, a prospective case series analysing the effects of patient compliance on outcomes of mandible fracture management. Compliance with post-operative instructions was measured with the following variables for each patient: soft diet, mouthwash, oral antibiotics, cigarette cessation, and review appointment attendance. In addition, a global compliance score was used. Eight outcome variables were analysed in relation to compliance: wound dehiscence, hardware exposure, local post-surgery infection, malocclusion, trismus, nerve damage, fracture non-union, and return to theatre. Results: Study 1. Delay was measured in days and ranged from zero to seventeen days, with a mean delay of 8.6 days. The incidence of unacceptable facial asymmetry, obvious facial scarring, trismus, and poor radiographic outcomes was 3%, 46%, 10% and 9% respectively. Statistically significant associations were found between delay and facial scarring, and delay and radiographic outcome. For each additional delay of a day, the odds of facial scarring being present, compared to absent, decreased by 13%. For regular cigarette users, for each additional day of delay there was a 306-fold increased risk of having a radiographic outcome of major deviation from premorbid compared to equivalent to premorbid. 4 Study 2. Delay was measured in days and ranged from zero to forty-one days, with a mean delay of 4.6 days. The incidence of wound dehiscence, hardware exposure, local post-operative infection, trismus, nerve damage, fracture nonunion and return to theatre was 6%, 4%, 11%, 8.5%, 47%, ...