Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice

Liu, Chang; Wu, Yin; Zha, Shuai; Liu, Mengping; Wang, Ying; Yang, Guangde; Ma, Kai; Fei, Yulang; Zhang, Yaojie; Hu, Xiaodan; Yang, Weina; Qian, Yi‐Hua

doi:10.1016/j.brainres.2015.11.040

Cited by 39 publications

(28 citation statements)

References 46 publications

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“…Tan IIA was the main effective components of anti-oxidative activity [17], adjustment to the blood lipid metabolism [28], improvement in rheology, body microcirculation, and activity of fibrinolysis [29]. Some research demonstrated that tan IIA markedly improved impaired nerve functions [17,30,31]. Hwang et al [19] showed that tan IIA improved ER stress-induced insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA reduces palmitate‐induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells

Wang

Hu²,

Chen

et al. 2019

Fundamemntal Clinical Pharma

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Research has indicated that stress on the endoplasmic reticulum (ER) of a cell affects the pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, and non‐alcoholic fatty liver disease (NAFLD). Palmitate, a saturated fatty acid, is known to induce toxicity and cell death in various types of cells. Tanshinone IIA (Tan IIA), one of the effective components of the traditional Chinese medicine Danshen, was reported to exhibit a variety of biochemical activities, including amelioration of ER stress‐mediated apoptosis in renal preservation. To address the hypothesis that tan IIA attenuates apoptosis and triglycerides (TG) accumulation via reducing ER stress, we studied the effect of tan IIA on experimentally induced ER stress using palmitate in HepG2 cells. Palmitate led to cytotoxicity, TG accumulation, and apoptosis in HepG2 cells and also strongly induced ER stress indicated by increased GRP78, phosphorylation of eIF2α, ATF6, and CHOP. Pretreatment with tan IIA (10 μm) significantly increased cell viability, decreased apoptotic cell death, and reduced the activity of caspase‐3. Meanwhile, tan IIA significantly decreased palmitate‐induced TG accumulation. Moreover, tan IIA significantly suppressed the phosphorylation of eIF2α, and inhibited GRP78, ATF6, and CHOP expression. In conclusion, tan IIA protects the HepG2 cells exposed to palmitate partially by inhibiting excessive ER stress, ER stress‐induced apoptosis, and hepatic steatosis. Therefore, tan IIA has therapeutic potential in the treatment of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Tanshinone IIA reduces palmitate‐induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells

Wang

Hu²,

Chen

et al. 2019

Fundamemntal Clinical Pharma

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“…Furthermore, TSN IIA treatment decreased the MDA content and increased SOD activity in rats with hypertension‐induced left ventricular hypertrophy [31]. Additionally, TSN IIA markedly reduced STZ‐induced elevation in acetylcholinesterase (AChE) activity and the MDA level and significantly inhibited STZ‐induced reduction in SOD and GSH‐Px activities in the parietal cortex and hippocampus [32]. Taken together, these results show that TSN IIA is a promising therapy target for DNP due to its antioxidant and neuroprotective features.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF‐κB signaling pathways

Feng

Qiu

2018

The Kaohsiung J of Med Scie

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The study aims to investigate whether tanshinone (TSN) IIA affects diabetic neuropathic pain (DNP) via the Nrf2/AR and NF-κB signaling pathways. Rats were randomly assigned into DNP group, TSN group (injected with TSN IIA), TSN + DRB group (injected with TSN IIA and 15 mg/kg Nrf2/ARE inhibitors), TSN + PDTC group (injected with TSN IIA and 60 mg/kg NF-κB inhibitors) or control group. The first four groups were successfully established as DNP models after injection of streptozotocin. The blood glucose level, mechanical withdrawal threshold (MWT), thermal withdrawal latency (TWL), nerve conduction velocity (NCV) and antioxidase level were detected. Transmission electron microscopy and toluidine blue staining were utilized to observe the sciatic nerve. RT-qPCR and western blot were used to measure expression levels of Nrf2/ARE and NF-κB signaling pathway-related genes. Blood glucose, malondialdehyde (MDA) and erythrocyte glutathione peroxidase (GSH-Px) levels as well as expression of Keap1 and NF-κB were increased in the TSN, TSN + DRB and TSN + PDTC groups compared to control group. Furthermore, the MWT, TWL, NVC, and superoxide dismutase (SOD) levels and expression of Nrf2, heme oxygenase 1 (HO-1) and inhibitory kappa B (IκB) decreased in the treatment groups. The TSN + DRB and TSN + PDTC groups showed similar trend when compared with the TSN group, while the opposite trend was observed in the TSN group when compared with the DNP group. Our study demonstrates that TSN IIA alleviates neuropathic pain by activating the Nrf2/ARE signaling pathway and inhibiting the NF-κB signaling pathway in diabetic rats.

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“…Tanshinone IIA (Tan IIA) is one of the main active ingredients extracted from the rhizome of the Salvia miltiorrhiza . Recent studies have elucidated the neuroprotective action and molecular mechanism of Tan IIA in vitro and in vivo, including AD . Recently, some reports have indicated that Tan IIA dramatically activated the ERK signalling pathway and induced autophagic cell death .…”

Section: Discussionmentioning

confidence: 99%

“…Tanshinone IIA (Tan IIA, Purity ≥ 95%, HPLC) was obtained from Chengdu Must Biotechnology Co, Ltd (CAS number: 568‐72‐9, Chengdu, China) and dissolved in rapeseed oil before use. The choice of tanshinone IIA doses was according to the reference …”

Section: Methodsmentioning

confidence: 99%

“…Tanshinone IIA has been extensively used in the treatment of cardiovascular disease and cerebrovascular disease . Additionally, Tanshinone IIA has been suggested efficacious in preventing memory deficits by ameliorating neuronal damage and protecting against Aβ 25–35 ‐induced neurotoxicity and the pathological features of AD . Of interest, a recent study demonstrated that Tanshinone IIA could markedly induce autophagic cell death in KBM‐5 leukaemia cells .…”

Section: Introductionmentioning

confidence: 99%

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Tanshinone IIA attenuates Aβ25–35-induced spatial memory impairment via upregulating receptors for activated C kinase1 and inhibiting autophagy in hippocampus

Zhu

Liao

Zhou

et al. 2017

Journal of Pharmacy and Pharmacology

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Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice

Cited by 39 publications

References 46 publications

Tanshinone IIA reduces palmitate‐induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells

Tanshinone IIA reduces palmitate‐induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells

Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF‐κB signaling pathways

Tanshinone IIA attenuates Aβ25–35-induced spatial memory impairment via upregulating receptors for activated C kinase1 and inhibiting autophagy in hippocampus

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