Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease

Yener, Görsev; Hünerli-Gündüz, Duygu; Yıldırım, Ebru; Aktürk, Tuba; Başar-Eroğlu, Canan; Bonanni, Laura; Percio, Claudio Del; Farina, Francesca R; Ferri, Raffaele; Güntekin, Bahar; Hajós, Mihály; Ibáñez, Agustín; Jiang, Yang; Lizio, Roberta; Lopez, Susanna; Noce, Giuseppe; Parra, Mario A.; Randall, Fiona; Stocchi, Fabrizio; Babiloni, Claudio

doi:10.1016/j.ijpsycho.2022.05.008

Cited by 11 publications

(2 citation statements)

References 371 publications

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“…In this context, the lower delta oscillatory responses in older subjects upon either the visual or auditory oddball paradigm are quite understandable, as healthy elderly individuals tend to show decreased attentional or decision-making focus. In previous studies, regardless of modality, delta ERO studies have shown decreased amplitudes at the frontal and central locations in Alzheimer’s disease (AD) [ 30 ], Lewy body dementia (LBD), and Parkinson’s disease (PD) dementia [ 31 ]. This finding indicates supramodal alterations in the anterior parts of the hemispheres in various dementia patients, differentiating them from healthy controls [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study

Yener,

Kıyı,

Düzenli-Öztürk

et al. 2024

Brain Sciences

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Earlier research has suggested gender differences in event-related potentials/oscillations (ERPs/EROs). Yet, the alteration in event-related oscillations (EROs) in the delta and theta frequency bands have not been explored between genders across the three age groups of adulthood, i.e., 18–50, 51–65, and >65 years. Data from 155 healthy elderly participants who underwent a neurological examination, comprehensive neuropsychological assessment (including attention, memory, executive function, language, and visuospatial skills), and magnetic resonance imaging (MRI) from past studies were used. The delta and theta ERO powers across the age groups and between genders were compared and correlational analyses among the ERO power, age, and neuropsychological tests were performed. The results indicated that females displayed higher theta ERO responses than males in the frontal, central, and parietal regions but not in the occipital location between 18 and 50 years of adulthood. The declining theta power of EROs in women reached that of men after the age of 50 while the theta ERO power was more stable across the age groups in men. Our results imply that the cohorts must be recruited at specified age ranges across genders, and clinical trials using neurophysiological biomarkers as an intervention endpoint should take gender into account in the future.

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Section: Discussionmentioning

confidence: 99%

Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study

Yener,

Kıyı,

Düzenli-Öztürk

et al. 2024

Brain Sciences

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“…A general slowing (a reduction of fast alpha, beta and gamma-band oscillations and increase of slower delta and theta-band oscillations) in resting-state EEG has been well-documented [ 82 ]. Further pathologies include a delayed gamma event-related latency in parietal regions in the visual oddball paradigm (VOP) [ 83 ] but also increased gamma connectivity in VOP [ 84 ] and reduced theta-gamma coupling during a WM task [ 85 ] (for full review see [ 86 ]). Conflicting results in resting-state EEG [ 82 ] may be overcome in combined TMS-EEG studies by evaluating TMS-induced perturbations.…”

Section: Discussionmentioning

confidence: 99%

Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

Biačková,

Adamová,

Klírová

2023

Eur Arch Psychiatry Clin Neurosci

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Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that, through its manipulation of endogenous oscillations, can affect cognition in healthy adults. Given the fact that both endogenous oscillations and cognition are impaired in various psychiatric diagnoses, tACS might represent a suitable intervention. We conducted a search of Pubmed and Web of Science databases and reviewed 27 studies where tACS is used in psychiatric diagnoses and cognition change is evaluated. TACS is a safe and well-tolerated intervention method, suitable for multiple-sessions protocols. It can be administered at home, individualized according to the patient'’s anatomical and functional characteristics, or used as a marker of disease progression. The results are varying across diagnoses and applied protocols, with some protocols showing a long-term effect. However, the overall number of studies is small with a great variety of diagnoses and tACS parameters, such as electrode montage or used frequency. Precise mechanisms of tACS interaction with pathophysiological processes are only partially described and need further research. Currently, tACS seems to be a feasible method to alleviate cognitive impairment in psychiatric patients; however, a more robust confirmation of efficacy of potential protocols is needed to introduce it into clinical practise.

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Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia

Jiang,

Neal,

Sompol

et al. 2024

Alzheimer's & Dementia

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Many coronavirus disease 2019 (COVID‐19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting “brain fog” and mild cognitive impairments even months after the acute phase of infection. Resting‐state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID‐19 and to Alzheimer's disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities. EEG abnormalities seen in COVID‐19 patients resemble those observed in early stages of neurodegenerative diseases, particularly ADRD. It is proposed that similar EEG abnormalities in Long COVID and ADRD are due to parallel neuroinflammation, astrocyte reactivity, hypoxia, and neurovascular injury. These neurophysiological abnormalities underpinning cognitive decline in COVID‐19 can be detected by routine EEG exams. Future research will explore the value of EEG monitoring of COVID‐19 patients for predicting long‐term outcomes and monitoring efficacy of therapeutic interventions.Highlights Abnormal intrinsic electrophysiological brain activity, such as slowing of EEG, reduced alpha wave, and epileptiform are characteristic findings in COVID‐19 patients. EEG abnormalities have the potential as neural biomarkers to identify neurological complications at the early stage of the disease, to assist clinical assessment, and to assess cognitive decline risk in Long COVID patients. Similar slowing of intrinsic brain activity to that of COVID‐19 patients is typically seen in patients with mild cognitive impairments, ADRD. Evidence presented supports the idea that cognitive deficits in Long COVID and ADRD are driven by overlapping neurophysiological abnormalities resulting, at least in part, from neuroinflammatory mechanisms and astrocyte reactivity. Identifying common biological mechanisms in Long COVID‐19 and ADRD can highlight critical pathologies underlying brain disorders and cognitive decline. It elucidates research questions regarding cognitive EEG and mild cognitive impairment in Long COVID that have not yet been adequately investigated.

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Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease

Cited by 11 publications

References 371 publications

Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study

Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study

Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia

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