2014
DOI: 10.1128/aac.01023-13
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Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species

Abstract: Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine su… Show more

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Cited by 49 publications
(42 citation statements)
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“…[12][13][14][15][16] One of the limitations of the present study was to lack the evaluation of a relationship between in vitro susceptibility with in vivo response to MF. However, these isolates were not from patients who used MF.…”
Section: 5mentioning
confidence: 99%
“…[12][13][14][15][16] One of the limitations of the present study was to lack the evaluation of a relationship between in vitro susceptibility with in vivo response to MF. However, these isolates were not from patients who used MF.…”
Section: 5mentioning
confidence: 99%
“…We have previously reported an inverse correlation between Leishmania ABCA3 gene expression in amastigotes and MLF susceptibility, supporting the possibility that higher expression of vesicular ABCA3 in the parasite could promote susceptibility through increased drug accumulation (22). Although not functionally validated, this hypothesis would suggest that ABCA3 inhibitors could induce drug resistance in the parasite.…”
Section: Discussionmentioning
confidence: 89%
“…Cultured cells were differentiated using 250 ng/ml PMA for 3 h and washed with PBS, and adherence was allowed for 24 h. (22)) were kept at 25°C in RPMI supplemented with 10% heat-inactivated FBS and 5 mg/ml hemin. L.p-LUC001 was maintained with additional 120 g/ml Geneticin and L.p-LUC056 cultured in the presence of 60 M MLF and 160 g/ml Geneticin.…”
Section: Cell Culture and Differentiationmentioning
confidence: 99%
“…Taking this into account, it would be desirable to develop active compounds against diverse Leishmania spp. ; however, the in vitro evidences of inter-species differences in the susceptibility of parasites to antileishmanial drugs have also been reported (Escobar et al, 2002;Obonaga et al, 2014). In recent years, considerable attention has been given to new compounds in an attempt to search for new antileishmanial drugs (Croft & Coombs, 2003;Khaliq et al, 2009;Seifert et al, 2010;Vendrametto et al, 2010).…”
Section: Discussionmentioning
confidence: 99%