Treatment for amphetamine dependence and abuse

Srisurapanont, Manit; Jarusuraisin, Ngamwong; Kittirattanapaiboon, Phunnapa

doi:10.1002/14651858.cd003022

Cited by 48 publications

(25 citation statements)

References 7 publications

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“…A particular attention should be given to suicidal ideation, as the withdrawal from methamphetamine is associated with a particularly severe and prolonged depression, even more than the one of cocaine. A Cochrane review showed that fluoxetine might have modest benefit in reducing short-term methamphetamine craving, but is of limited interest since it did not permit a reduction in methamphetamine use [179]. In that paper, it is stated that imipramine can help in maintaining people in therapy.…”

Section: Resultsmentioning

confidence: 99%

The Health Effect of Psychostimulants: A Literature Review

Favrod-Coune

Broers

2010

Pharmaceuticals

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Prevalence of psychostimulant use is high, and raising in several countries. Nicotine is the legal stimulant causing the most important public health impact. Cocaine ranks among the most used illicit substances after cannabis. Stimulant medications are frequently misused. Psychostimulants can lead to addiction, have physical, psychological and social health consequences and can induce a great disease burden. The aim of the present article is to provide a literature review on the health effects of stimulants as potential drugs of abuse. It will cover essentially cocaine, amphetamines and its derivatives (including methamphetamines and 3-4-methylenedioxymethamphetamine, ecstasy), nicotine, caffeine and khat, and touch upon the issues of prescribed substances (anti-depressants, weight control medications, attention-deficit hyperactivity disorder medications, hypersomniac disorder). Their pharmacology, addictive potential, health consequences and treatment will be discussed. We used Medline for the literature review from 1990 to the date of this review, and mention the findings of human and animal studies (the latter only if they are of clinical relevance).

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Section: Resultsmentioning

confidence: 99%

The Health Effect of Psychostimulants: A Literature Review

Favrod-Coune

Broers

2010

Pharmaceuticals

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“…MA addiction produces serious medical complications, and imposes costly social burdens [1,4]. In addition, MA dependence is resistant to treatment, with psychosocial interventions providing help to only some affected individuals [5,6], and no medications proven to be effective in treating this disorder [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Withdrawal symptoms in abstinent methamphetamine‐dependent subjects

et al. 2010

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Aims Withdrawal symptoms have been linked to a propensity for relapse to drug abuse. Inasmuch as this association applies to methamphetamine (MA) abuse, an understanding of the course of MA withdrawal symptoms may help to direct treatment for MA dependence. Previous studies of symptoms manifested during abstinence from MA have been limited in size and scope. We asked (i) whether debilitating psychological and/or physical symptoms appear during the first several weeks of MA abstinence, (ii) how craving for MA evolves and (iii) whether psychiatric symptoms (e.g. depression, psychosis) persist beyond a month of abstinence. Design A study of MA-dependent participants, who initiated and maintained abstinence from the drug for up to 5 weeks, compared to a matched healthy comparison group. Setting In-patient research hospital ward (MA-dependent subjects) and out-patient (comparison subjects). Participants Fifty-six MA-dependent and eighty-nine comparison subjects. Measurements Rater-assessed MA withdrawal questionnaire and self-report assessment of craving (MA-dependent subjects) and self-report assessment of psychiatric symptoms (both groups). Findings At study entry, MA-dependent subjects exhibited a wide range in severity of depressive symptoms, with the average score at a mild–moderate level of severity. Symptoms of psychosis were also prevalent. While depressive and psychotic symptoms largely resolved within a week of abstinence, craving did not decrease significantly from the time of initiating abstinence until the second week, and then continued at a reduced level to the fifth week. Conclusions Depressive and psychotic symptoms accompany acute withdrawal from methamphetamine but resolve within 1 week. Craving is also present and lasts at least 5 weeks.

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“…Dysregulation of reward‐related glutamate pathways, as observed in cocaine use, represents a further potential neurobiological substrate for methamphetamine dependence [7,9,10]. Despite increasing knowledge of the neurobiological consequences of methamphetamine use, no medications to date have been any more successful than placebo in reducing methamphetamine use in dependent patients [11,12].…”

Section: Introductionmentioning

confidence: 99%