Treatment for ataxia in multiple sclerosis

Mills, Roger; Yap, L.; Young, Carolyn A

doi:10.1002/14651858.cd005029.pub2

Cited by 90 publications

(67 citation statements)

References 61 publications

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“…In addition, OTs target movement-related functions as a prerequisite for an individual when undertaking basic mobility or grabbing things (70)(71)(72)(73). The categories "b5105 Swallowing" and "b51050 Oral swallowing" were only identified by a small number of OTs.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Comprehensive ICF Core Set for Multiple Sclerosis from the perspective of occupational therapists

Conrad

Coenen

Schmalz

et al. 2012

Scandinavian Journal of Occupational Therapy

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Section: Discussionmentioning

confidence: 99%

Validation of the Comprehensive ICF Core Set for Multiple Sclerosis from the perspective of occupational therapists

Conrad

Coenen

Schmalz

et al. 2012

Scandinavian Journal of Occupational Therapy

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“…The most recent Cochrane review of treatments for ataxia in MS (which reviewed six randomized placebo-controlled trials) concluded that absolute and comparative efficacy and tolerability of pharmacotherapies are poorly documented and no recommendations could be made (53). Small open label studies or case reports have suggested benefits for a range of drugs for the treatment of tremor.…”

Section: Treatments For Cerebellar Disease In Msmentioning

confidence: 99%

“…In the Cochrane review, one neurosurgical study of thalamotomy versus thalamic stimulation was included (53). Tremor was abolished by both thalamotomy and thalamic stimulation in all patients immediately postsurgery (66).…”

Section: Treatments For Cerebellar Disease In Msmentioning

confidence: 99%

Cerebellar Dysfunction in Multiple Sclerosis

Wilkins

2017

Front. Neurol.

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Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trials has raised the hope that cerebellar symptoms will be better treated in the future.

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“…Medications for ataxia are similar to those used for treating tremors (isoniazid, clonazepam, propanolol, gabapentin, and Ondansetron). A recent systematic review found no evidence that medication or neurorehabilitation strategies provide sustained improvement in ataxia in pwMS [67]. Surgical interventions such as thalamotomy or thalamic stimulation in MS have produced limited success.…”

Section: Symptomatic Management and Rehabilitationmentioning

confidence: 99%

Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis

Khan

Amatya

Turner-Stokes

2011

Neurology Research International

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Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting and secondary progressive MS types. Multiple system involvement at onset and rapid early progression have a worse prognosis. PPMS can cause significant disability and impact on quality of life. Recent studies are biased in favour of relapsing remitting patients as treatment is now available for them and they are more likely to be seen at MS clinics. Since prognosis for PPMS is worse than other types of MS, the focus of rehabilitation is on managing disability and enhancing participation, and application of a “neuropalliative” approach as the disease progresses. This chapter presents the symptomatic treatment and rehabilitation for persons with MS, including PPMS. A multidisciplinary approach optimizes the intermediate and long-term medical, psychological and social outcomes in this population. Restoration and maintenance of functional independence and societal reintegration, and issues relating to quality of life are addressed in rehabilitation processes.

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Treatment for ataxia in multiple sclerosis

Cited by 90 publications

References 61 publications

Validation of the Comprehensive ICF Core Set for Multiple Sclerosis from the perspective of occupational therapists

Validation of the Comprehensive ICF Core Set for Multiple Sclerosis from the perspective of occupational therapists

Cerebellar Dysfunction in Multiple Sclerosis

Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis

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