Treatment for HIV prevention study in southwestern areas of China

Abstract

BackgroundChina has ambitious to achieve significant reductions in HIV transmission and HIV-related mortality by adopting the World Health Organization's “Treat All” approach. Such a prevention strategy is needed future study on regional scale.MethodsAn observational cohort study of HIV epidemiology and treatment databases was used to study the effectiveness of antiretroviral therapy on the transmission of HIV in serodiscordant couples in Guangxi of China.ResultsA total of 7713 couples were entered into the cohort study analysis which included 1885 couples in the treatment-naive cohort and 5828 couples in the treated cohort. During the follow-up of 18985.29 person-years from 2003 to 2014, the average incidence of HIV was 2.4 per 100 person-years (95% CI 2.1–2.6). HIV seroincidence rate was significantly higher among the treatment naive group (4.2 per 100 person-years, 3.7–4.8) compared with the on treatment group (1.6 per 100 person-years, 1.3–1.8). An overall 45% reduction in risk of HIV transmission among serodiscordant couple was associated with ART treatment (adjusted Hazard Ratio [HR] 0.55, 95% Confidence Interval [CI] 0.44–0.69). Treatment prevention had significantly effectiveness for most baseline characteristics of index partners, such as for male, female, age above 25 years, education below high school, farmer, infected by heterosexual intercourse.ConclusionTreatment-as-prevention can be implemented in the real-world on a national or regional scale, but ART adherence and comprehensive harm reduction while implementing this strategy require further study.

HIV Epidemiology and Prevention in Southwestern China: Trends from 1996-2017

“…By the end of 2017, 70.2% of the people living with HIV knew their HIV status, 76.8% of the people who knew their HIV-positive status were receiving treatment, and 96.8% of the people receiving treatment had suppressed viral loads in Guangxi [96]. An observational cohort study of HIV epidemiology and treatment databases among serodiscordant couples in Guangxi showed that HIV seroincidence rate was significantly higher among the treatment-naive group (4.2 per 100 person-years, 3.7-4.8) compared with the treatment group (1.6 per 100 person-years, 1.3-1.8) [97]. This corresponded to an overall 45% reduction in risk of HIV transmission among serodiscordant couples who were on ART treatment.…”

Prevalence and factors associated with late diagnosis among older adults living with HIV in liuzhou, China: 2010−2020

“…This study was limited as it concentrated on a city in southwestern China, only patients from Liuzhou were included in this study, so the generalizability to other healthcare settings and regions may be limited. Nevertheless, the southwestern region of China contains the most significant number of new HIV infections 32 . Thus this study may be relevant to a substantial part of the current HIV epidemic.…”

Risk of Sexual Transmission of HIV with Antiretroviral Therapy and Variable or Suppressed Viral Load

“…Of these potentially relevant articles, 72 publications were excluded for various reasons, while 15 studies met the inclusion criteria and were included in this report. 13,14,[18][19][20][21][22][23][24][25][26][27][28][29][30] These comprised 1 overview of SRs and/or MAs, 18 and 14 nonrandomized studies. 13,14,[19][20][21][22][23][24][25][26][27][28][29][30] Appendix 1 presents the PRISMA 31 flow chart of the study selection.…”

“…13,14,[18][19][20][21][22][23][24][25][26][27][28][29][30] These comprised 1 overview of SRs and/or MAs, 18 and 14 nonrandomized studies. 13,14,[19][20][21][22][23][24][25][26][27][28][29][30] Appendix 1 presents the PRISMA 31 flow chart of the study selection.…”