A dentigerous cyst is a benign and asymptomatic lesion that may become extremely large and then interfere with tooth eruption. Marsupialization is known as the best treatment option for large cysts involving an unerupted permanent tooth. A 16-year-old female has been referred with the chief complaint of an unerupted tooth, extraoral and intraoral swelling, and pain. Radiographic examination demonstrated a unilocular, well-defined, and large radiolucent lesion extended from the distal of the right mandibular canine approximately to the left first mandibular molar. The mandibular left canine was also embedded within the lesion. The selected treatment plan was marsupialization, followed by performing orthodontic treatment of the unerupted mandibular canine. This clinical report presented the successful eruption of an impacted mandibular canine over a 4-years follow-up. The findings of this study revealed that the combination of marsupialization and orthodontic treatment is an effective treatment for large jaw cysts with impacted teeth.