“…Efforts have been made to develop design rules based on comparing it with the corresponding batch process [1,2] or to elucidate basic mechanisms, for example, the impurity incorporation and carryover [3]. Additionally, novel concepts, applying to example slug-flow [4], oscillatory baffled [5,6], Couette-Taylor [7,8] or fluidized bed crystallizers [9][10][11][12], as well as columns with static mixers [1] or coiled flow inverters [13], have been developed lately. These concepts exploiting tubular crystallizers in general are not superior nor applicable for every substance system or separation problem.…”