Treatment of a<i>Staphylococcus lugdunensis</i>cervical epidural abscess

Noh, Thomas; Zervos, Thomas M; Chen, Anne; Chedid, Mokbel

doi:10.1136/bcr-2018-227449

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…El principal germen involucrado suele ser Staphylococcus aureus. La diseminación hematógena es la causa más (3,(6)(7)(8) frecuente, pero puede ser también ocasionada por extensión local . La resonancia magnética contrastada con gadolinio es la técnica de elección para el diagnóstico del empiema medular, (3,6,7) facilitando su ubicación precisa y la valoración del compromiso medular .…”

Section: Discussionunclassified

Síndrome de compresión medular de etiología infecciosa

Dávalos Ortiz,

Sobarzo Vysokolán,

Garcete Espínola

2023

Rev. virtual Soc. Parag. Med. Int.

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El síndrome de compresión medular es una urgencia neuroquirúrgica debido a que un diagnóstico precoz y un tratamiento temprano podría revertir las incapacitantes secuelas ocasionadas por esta enfermedad. Las causas de este síndrome pueden ser traumática, metastásica, infecciosa y vascular (hematomas). La etiología infecciosa no es frecuente y el principal germen involucrado suele ser Staphylococcus aureus. A continuación presentamos el caso de una paciente de 58 años con síndrome de compresión medular de etiología infecciosa quien fue ingresada en el Servicio de Clínica Médica del Centro Médico Nacional.

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Section: Discussionunclassified

Síndrome de compresión medular de etiología infecciosa

Dávalos Ortiz,

Sobarzo Vysokolán,

Garcete Espínola

2023

Rev. virtual Soc. Parag. Med. Int.

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“…A literature review identified nine case reports of the use of cefazolin for spinal epidural abscesses (SEAs) (Table 4). [37][38][39][40][41][42][43][44][45]57,58 Seven patients had MSSA, one had Group G Streptococcus, and one had methicillin-susceptible Staphylococcus lugdunensis. Only one case described the use of cefazolin for empirical therapy, five described cefazolin as definitive therapy after culture results were available, and three did not specify.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation

et al. 2023

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Infections of the central nervous system (CNS) are complex to treat and associated with significant morbidity and mortality. Historically, antistaphylococcal penicillins such as nafcillin were recommended for the treatment of methicillin‐susceptible staphylococcal CNS infections. However, the use of antistaphylococcal penicillins presents challenges, such as frequent dosing administration and adverse events with protracted use. This narrative reviews available clinical and pharmacokinetic/pharmacodynamic (PK/PD) data for cefazolin in CNS infections and produces a recommendation for use. Based on the limited available evidence analyzed, dose optimized cefazolin is likely a safe and effective alternative to antistaphylococcal penicillins for a variety of CNS infections due to methicillin‐susceptible Staphylococcus aureus. Given the site of infection and wide therapeutic index of cefazolin, practitioners may consider dosing cefazolin regimens of 2 g IV every 6 h or a continuous infusion of 8–10 g daily instead of 2 g IV every 8 h to optimize PK/PD properties.

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Cervical Spinal Epidural Abscess: Diagnosis, Treatment, and Outcomes: A Case Series and a Literature Review

Papadakis,

Ampadiotaki,

Pallis

et al. 2023

JCM

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Although recent diagnostic and management methods have improved the prognosis of cervical epidural abscesses, morbidity and mortality remain significant. The purpose of our study is to define the clinical presentation of cervical spinal epidural abscess, to determine the early clinical outcome of surgical treatment, and to identify the most effective diagnostic and treatment approaches. Additionally, we analyzed studies regarding cervical epidural abscesses and performed a review of the literature. In this study, four patients with spinal epidural abscess were included. There were three men and one woman with a mean age of 53 years. Three patients presented with motor deficits, and one patient was diagnosed incidentally through spinal imaging. All the patients had fever, and blood cultures were positive. Staphylococcus aureus was the most common organism cultured from abscesses. All patients underwent a surgical procedure, and three patients recovered their normal neurological functions, but one remained with mild neurological disability that was resolved two years postoperatively. The mean follow-up period was 12 months, and no deaths occurred in this series. Furthermore, we identified 85 studies in the literature review and extracted data regarding the diagnosis and management of these patients. The timely detection and effective management of this condition are essential for minimizing its associated morbidity and mortality.

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Treatment of aStaphylococcus lugdunensiscervical epidural abscess

Cited by 3 publications

References 14 publications

Síndrome de compresión medular de etiología infecciosa

Síndrome de compresión medular de etiología infecciosa

Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation

Cervical Spinal Epidural Abscess: Diagnosis, Treatment, and Outcomes: A Case Series and a Literature Review

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