Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: Combined results of two double-blind investigations

Lookingbill, Donald P.; Chalker, Dan K.; Lindholm, Jane S.; Katz, Harry Irving; Kempers, Stephen E.; Huerter, Christopher J.; Swinehart, James M.; Schelling, Donald; Klauda, Harry C.

doi:10.1016/s0190-9622(97)70177-4

Cited by 148 publications

(87 citation statements)

References 10 publications

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“…Overall, the results of this study are limited due to being underpowered. However, they highlight trends that support previous literature (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 84%

“…What is specifically appealing about combination products is the synergistic effects affording increased efficacy without significantly affecting safety or tolerability (8)(9)(10)(11). In this small observational study, the hazards of treatment failure resulting in treatment modifications were consistent between patients initially prescribed a single product, multiple products, or a combination project.…”

Section: Discussionmentioning

confidence: 99%

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Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Carstensen

Huang

Feldman

2013

Journal of Dermatological Treatment

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Background: While limited data from clinical trials show differences in efficacy between topical acne combination products and monotherapies, the impact in clinical practice is not explored. Purpose: To evaluate the effectiveness in clinical practice of prescribing topical acne combination treatments compared to monotherapy product(s) in minimizing treatment failures. Methods: Patients diagnosed with acne (ICD-9: 706.1) by a dermatologist between January 2009 and September 2011 and initially prescribed a topical acne treatment were identified. Multivariate Cox proportional hazards models were employed to compare the hazards of treatment failure for patients initially prescribed a combination product versus one monotherapy or multiple monotherapies. Subgroup analyses were also performed. Results: Three hundred and thirty-five patients were initially prescribed topical product(s) exclusively. The hazards of treatment failure for those prescribed a combination product compared to those prescribed one monotherapy product was HR = 0.91 (p = 0.65) and compared to those prescribed multiple monotherapy products was HR = 0.73 (p = 0.17). Limitations: Disease severity and treatments prescribed outside of the hospital system were not available. Conclusions: Treatment failures were consistent for patients prescribed combination product(s) or monotherapies.

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“…Overall, the results of this study are limited due to being underpowered. However, they highlight trends that support previous literature (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Carstensen

Huang

Feldman

2013

Journal of Dermatological Treatment

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“…They used spontanecus reports cf isotretincin expcsed pregnancies that were voluntarily submitted to the manufacturer cf the drug (Hcffmann-La Roche Inc.) in the US frcm September 1982 te July 1989. The repens cf 433 isotretincin-exposed were obtained, but timing cf conception in relation te isctretinoin exposure was kncwn for only 396 49 women. 0f these, 133 (33%) were already pregnant before isotretinoin therapy was initiated, and 65 (16%) patients became pregnant in the first three weeks of isotretinoin use.…”

Section: Isotretinoin Utilizationmentioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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“…Lookingbill et al performed an 11-week, double-blind, randomized, parallel, controlled study of 334 subjects comparing BPO/clin (5%/1%) to monotherapy of either drug of similar concentrations or vehicle. 44 The BPO/clin combination had greater efficacy than monotherapy of either drug or vehicle, and the combination drug was well-tolerated.…”

Section: Combination Bpo and Clindamycin (Bpo/clin)mentioning

confidence: 97%

Retinoid plus antimicrobial combination treatments for acne

2012

Journal of the American Academy of Dermatology

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Background: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. Purpose: To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris. Methods: A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide. Results: Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect. Conclusions: Combination medications have superior efficacy and adherence, and have a similar tolerability profile compared with monotherapy of its components. Several studies have found antibiotic-containing combination products with a retinoid effective for acne. The use of antibiotic-containing combination medications for acne can lead to bacterial resistance. Due to this potential for bacterial resistance, benzoyl peroxide treatments are also recommended in combination with a retinoid.

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Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: Combined results of two double-blind investigations

Cited by 148 publications

References 10 publications

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Retinoid plus antimicrobial combination treatments for acne

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