Treatment of acquired reactive perforating collagenosis with allopurinol

Querings, Kerstin; Balda, Bernd‐Rüdiger; Bachter, D.

doi:10.1046/j.1365-2133.2001.04310.x

Cited by 27 publications

(30 citation statements)

References 13 publications

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“…Allopurinol has been reported to be effective in treating acquired reactive perforating collagenosis (ARPC), [41][42][43][44] a condition in which altered collagen is eliminated through the epidermis. Resolution of lesions in ARPC by oral allopurinol has been described in patients with both type 1 and type 2 diabetes with or without hyperuricemia (see table II).…”

Section: Cutaneous Adverse Effects Of Allopurinolmentioning

confidence: 99%

Allopurinol in Dermatology

Tsai

Yeh

2010

American Journal of Clinical Dermatology

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Off-label use is common in dermatology, and is inevitable for rare cutaneous diseases such as perforating dermatosis. Allopurinol is traditionally considered to be a drug for hyperuricemia only, but the recent demonstration of its efficacy in congestive heart failure has spurred renewed interest in its application in other clinical specialties. In dermatology, allopurinol is best known for its severe cutaneous adverse reactions. Recent genomic studies conducted in Taiwan have discovered useful HLA markers for determining the susceptibility of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with allopurinol. Allopurinol has also been used in a number of dermatologic disorders including acquired reactive perforating collagenosis, sarcoidosis, psoriasis and granulomas caused by methacrylate microspheres, silicon and tattoos. Allopurinol may express its therapeutic effects via its antioxidation or anti-inflammatory properties, or its ability to improve vascular function.

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Section: Cutaneous Adverse Effects Of Allopurinolmentioning

confidence: 99%

Allopurinol in Dermatology

Tsai

Yeh

2010

American Journal of Clinical Dermatology

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“…In both cases, oral allopurinol 100 mg a day resulted in resolution of the lesions of APD within 1–2 weeks. In a further case of Querings et al [32], in a patient with a normal uric acid level, allopurinol was also effective in a short time. Apart from his xanthine oxidase activity, allopurinol acts as a free radical scavenger.…”

Section: Discussionmentioning

confidence: 99%

“…Different treatments have been supposed with different results: topical or intralesional steroids, UVB, bath-psoralen UVA therapy [9], topical and systemic retinoids [30], systemic antihistamines and allopurinol [31, 32]. Krüger et al [31]reported on 2 women with APD associated with hyperuricaemia, diabetic condition and mild renal insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Acquired Perforating Dermatosis in a Patient with Poland Syndrome

Fistarol

Itin²

2003

Dermatology

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Acquired perforating dermatosis (APD) is characterized by umbilicated 1- to 10-mm-measuring papulonodules with a central adherent oystershell-like keratotic plug, typically on the dorsa of the hands, forearms and over the knees. APD is associated with systemic diseases, especially diabetes mellitus and/or renal failure. Histologically the lesions show transepidermal elimination of altered dermal components into a cup-shaped epidermal depression. We present a 69-year-old man with coexisting APD and Poland syndrome (PS), an association not yet described. PS (OMIM 173800) is a rare congenital anomaly consisting of unilateral partial or total absence of the greater pectoralis muscle and ipsilateral symbrachydactyly. Most cases of PS are sporadic as it was in our case. Our patient had, in addition, an untreated diabetic condition, hyperuricaemia, dilated cardiomyopathy and a very recent pulmonary embolism. He responded to therapy with allopurinol.

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“…In der Literatur wurde über die Anwendung von Allopurinol bei elf Patienten berichtet; bei 10 von ihnen trat eine deutliche Besserung oder Abheilung ein [1,2,3,4,5,7,8]. Die pharmakologische Wirkung wird vornehmlich auf die Reduktion oxidativen Stresses zurückgeführt.…”

Section: Diskussionunclassified

“…Weitere Einzelberichte beschreiben den topischen Einsatz keratolytischer und steroidhaltiger Externa sowie einer Photo(chemo)therapie [5]. Systemisch wurde auch mit Antihistaminika, Retinoiden, Doxycyclin oder Glukokortikosteroiden behandelt, wobei als effektivste Therapie die tägliche Gabe von niedrigdosiertem Allopurinol beschrieben ist [8]. Allopurinol und eine Creme-PUVA konnten auch bei unserem Patienten den Krankheitsprogress stoppen.…”

Section: Diskussionunclassified