Treatment of actinic keratosis: a systematic review

Worley, Brandon; Harikumar, Vishnu; Reynolds, Kelly A; Dirr, McKenzie A.; Christensen, Rachel E.; Anvery, Noor; Yi, Michael D; Poon, Emily; Alam, Murad

doi:10.1007/s00403-022-02490-5

Cited by 19 publications

(36 citation statements)

References 64 publications

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“…It was widely used in the treatment of tumors, such as breast cancer, prostate cancer, skin lesions, and liver cancer. [7][8][9][10] The mechanism of this procedure is that the ultra-low temperature can cause cell necrosis and apoptosis. [2] In order to achieve the goal of sphincter preservation, cryosurgery was employed in this patient post-CRT.…”

Section: Discussionmentioning

confidence: 99%

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

et al. 2023

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Rationale: In the treatment of low rectal cancer (LRC), preserving the anal sphincter is increasingly attracting the attention of colorectal surgeons. Many patients refused to perform a colostomy. Here, we report a case of LRC in a middle-aged woman and the clinical implications of the symptom, the treatment process of LRC, and the complications. Patient concerns: A 46-year-old woman visited our department with a tumor found on her physical examination because of hemafecia. Then she refused to perform abdominoperineal resection. Diagnosis: The patient first completed a colonoscopy and then underwent a rectal biopsy. The tumor was diagnosed as a rectal adenocarcinoma after pathological evaluation. Then it was staged by magnetic resonance imaging and enhanced computed X-ray tomography. Interventions: The treatment consisted of chemoradiotherapy followed by cryoablation. Outcomes: The patient achieved a good oncological outcome and preserved the sphincter successfully. The post-cryoablation course of the patient was uneventful and he remained healthy at the 1-year follow-up. Lessons: The preservation of anal sphincters has attracted more and more attention from colorectal surgeons. From the patient's perspective, the preservation of the anal sphincter was a key part of her treatment. We should try to meet the wishes of patients on the basis of curing the disease.

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Section: Discussionmentioning

confidence: 99%

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

et al. 2023

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“…imiquimod for field damage. 7 Choices are based on the site and type of lesion, patient preference and access to treatment modalities.…”

Section: Chitra Nairmentioning

confidence: 99%

“…The aims of treatment are to improve the cosmetic appearance and, more significantly, reduce the risk of developing a skin cancer. Treatment modalities range from cryotherapy for individual lesions to photodynamic therapy and topical agents like 5‐fluorouracil and imiquimod for field damage 7 . Choices are based on the site and type of lesion, patient preference and access to treatment modalities.…”

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confidence: 99%

Prevention, diagnosis and treatment of actinic keratosis

Nair

2024

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“…It is well known that lesion-directed therapies (such as cryotherapy, surgical courettage, and carbon dioxide [CO 2 ] fully-ablative laser) and field-directed approaches such as photodynamic therapy (PDT) and CO 2 -fractional laser resurfacing (FXL) can be considered. 15 In recent years, this latter technique has been used for a comprehensive approach to damaged actinic area. The CO 2 -FXL laser, with a wavelength of 10,600 nm, has a reduced risk of scarring compared with fully ablative lasers.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical and chemical treatments can be effective in treating precancerous lesions, although they can be extremely disfiguring and difficult for the patient to bear, as well as costly to the national health system. It is well known that lesion‐directed therapies (such as cryotherapy, surgical courettage, and carbon dioxide [CO 2 ] fully‐ablative laser) and field‐directed approaches such as photodynamic therapy (PDT) and CO 2 ‐fractional laser resurfacing (FXL) can be considered 15 . In recent years, this latter technique has been used for a comprehensive approach to damaged actinic area.…”

Section: Introductionmentioning

confidence: 99%

IGF1 synthesis after CO₂ fractional laser resurfacing (FLR): New insights in the treatment of scalp actinic keratoses

et al. 2023

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ObjectivesActinic keratosis have a high risk of progression to a squamous cell carcinoma. Insulin‐like growth factor 1 and its receptor play a relevant role in restoring repair of ultraviolet‐induced cell damage. This pathway is reduced in patients older than 65 years. Ablative fractional laser resurfacing could normalize insulin‐like growth factor 1 (IGF‐1) secretion in elderly by recruiting new fibroblasts. The aim of the study is to evaluate restoration of IGF1 values by PCR in senescent fibroblasts after ablative fractional laser resurfacing.MethodsWe enrolled 30 male patients with multiple actinic keratosis on the scalp, equally divided into two mirror areas of up to 50 cm2, treating only the right one. We performed one skin biopsy for each area 30 days after treatment. Real‐time PCR in fibroblasts was performed to assess the change in IGF1. At baseline and after 6 months, in vivo reflectance confocal microscopy examination was performed in all patients.ResultsIGF1 values were increased in the treated side by about 60%. The right areas had fairly complete resolution of actinic keratosis at the last follow‐up visit after 6 months with no appearance of new lesions. The mean number of actinic keratosis in the right area was reduced by more than 75% at four‐ and six‐follow‐up visits compared to the left area. The improvement in the right area was also evidenced by lower values of the mean AKASI (actinic keratosis area and severity index) score. Reflectance confocal microscopy showed a reduction of keratinocytic disarray and scales after treatment.DiscussionTaken together, all the clinical, laboratory, and in vivo results of our study allowed us to confirm that ablative fractional laser resurfacing is a valuable tool for the treatment of actinic keratosis and cancerization field, both for the management of clinically evident lesions and for preventing the occurrence of squamous cell carcinoma.

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Treatment of actinic keratosis: a systematic review

Cited by 19 publications

References 64 publications

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

Prevention, diagnosis and treatment of actinic keratosis

IGF1 synthesis after CO₂ fractional laser resurfacing (FLR): New insights in the treatment of scalp actinic keratoses

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Treatment of actinic keratosis: a systematic review

Cited by 19 publications

References 64 publications

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review

Prevention, diagnosis and treatment of actinic keratosis

IGF1 synthesis after CO2 fractional laser resurfacing (FLR): New insights in the treatment of scalp actinic keratoses

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IGF1 synthesis after CO₂ fractional laser resurfacing (FLR): New insights in the treatment of scalp actinic keratoses