Treatment of Acute Gonorrheal Pelvic Inflammatory Disease: The Use of Benzathine Penicillin G in the Ambulatory Patient

Landman, Gerda S.; Phillips, L. V.; Friend, L.

doi:10.1097/00007611-195807000-00018

Cited by 11 publications

(4 citation statements)

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“…In 2012, 334,826 gonococcal infections were reported in the United States, representing a continuing gradual increase over the preceding 4 years (1). In women, Neisseria gonorrhoeae is a major cause of pelvic inflammatory disease, ectopic pregnancy, and infertility (2,3). Public health control of gonorrhea relies on prompt detection and effective treatment.…”

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confidence: 99%

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013

Kirkcaldy

Soge

Papp

et al. 2015

Antimicrob Agents Chemother

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e Azithromycin, administered with ceftriaxone, is recommended by the CDC for the treatment of gonorrhea. Many experts have expressed concern about the ease with which Neisseria gonorrhoeae can acquire macrolide resistance. We sought to describe gonococcal azithromycin susceptibility in the United States and to determine whether azithromycin susceptibility has changed over time. We analyzed data from 2005 to 2013 from the Gonococcal Isolate Surveillance Project, a CDC-supported sentinel surveillance network that monitors gonococcal antimicrobial susceptibility. A total of 44,144 N. gonorrhoeae isolates were tested for azithromycin susceptibility by agar dilution methods. The overall azithromycin MIC 50 was 0.25 g/ml, and the MIC 90 was 0.5 g/ml. There were no overall temporal trends in geometric means. Isolates from men who had sex with men had significantly higher geometric mean MICs than isolates from men who had sex exclusively with women. The overall prevalence of reduced azithromycin susceptibility (MIC, >2 g/ml) was 0.4% and varied by year from 0.3% (2006 and 2009) to 0.6% (2013). We did not find a clear temporal trend in gonococcal azithromycin MICs in the United States, and the prevalence of reduced azithromycin susceptibility remains low. These findings support the continued use of azithromycin in a combination therapy regimen for gonorrhea.

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confidence: 99%

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013

Kirkcaldy

Soge

Papp

et al. 2015

Antimicrob Agents Chemother

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show abstract

“…A further disadvantage of benzathine penicillin is that local pain from the injection is more common (and more severe) than from PAM (Gallego 1956). Nevertheless benzathine penicillin has proved useful in the treatment of the complications of gonorrhoea, particularly of pelvic inflammatory disease (Land‐man et al 1958) as it has, with and without oestrogens, in the treatment of vulvo‐vaginitis in young girls (Morales Gonzales and Conejo Mir 1956).…”

Section: Penicillin By Intramuscular Injectionmentioning

confidence: 99%

Treatment of Gonorrhoea with Penicillin Preparations

Willcox

1962

Int J Clinical Practice

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“…Even with large doses of benzathine penicillin (e.g., 2.4 mega-units) it has been concluded that, while this may provide a penicillinaemia for 50 or more days sufficient to kill 95 % of all strains, it is not sufficient for the most resistant ones (Schamberg et al, 1958). Benzathine penicillin fortified by PAM has consequently been tried in some areas (Hookings & Graves, 1956;Landman et al, 1958), and has been found to reduce case incidence. '…”

Section: Increased Doses Of Repository Penicillinsmentioning

confidence: 99%

Treatment Problems of Gonorrhoea

Willcox¹

1961

Obstetrical & Gynecological Survey

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Treatment of Acute Gonorrheal Pelvic Inflammatory Disease: The Use of Benzathine Penicillin G in the Ambulatory Patient

Cited by 11 publications

References 0 publications

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013

Treatment of Gonorrhoea with Penicillin Preparations

Treatment Problems of Gonorrhoea

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