Treatment of Acute Mountain Sickness and High Altitude Pulmonary Oedema

Kapoor, Rajan; Narula, AS; Anand, Anil C.

doi:10.1016/s0377-1237(04)80018-2

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…High altitude sickness is a growing concern due to the increased number of travelers, sportspersons, adventurers, pilgrims, army personnel, and even non‐resident locals living at high altitude >2,500 m (Kapoor, Narula, & Anand, 2004; Paralikar & Paralikar, 2010). Mild to life‐threatening clinical conditions such as acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), high altitude cerebral edema (HACE), and High‐altitude pulmonary hypertension (HAPH), have been reported (Kapoor et al, 2004) at high altitude. The physiological effects of high altitude begin at 1,500–3,500 m (m) and gradually increase at 3,500–5,500 m and become severe at extremely high altitude (above 5,500 m) (Paralikar & Paralikar, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of mindfulness meditation protocol in subjects with various psychometric characteristics at high altitude

et al. 2020

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Introduction Incidence of high altitude‐related sickness is increasing due to more number of people visiting the areas of high altitude which may result in life‐threatening conditions including acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), high altitude cerebral edema (HACE), and High‐altitude pulmonary hypertension (HAPH). We hypothesized that an advanced yoga regimen may be beneficial in dealing with the physiology of acclimatization. Methods Anthropometric, Biochemical, and Psychological assessments were carried out in 48 participants before and after the advance meditation program (AMP) in the experimental group. Individuals with an age range of 20–65 years with no comorbidities were included in the study. Participants were exposed to AMP for 4 days. All assessments were carried out at the baseline and after the course. Prakriti was constituted for all participants using a standard questionnaire. The study was carried out after obtaining the written informed consent as per the guidelines outlined by the Institute Ethics Committee. Results Po2 and glucose levels were found significantly reduced along with changes in the Happiness index, anxiety, and mental well‐being. However, participants with lowered Po2, after 4 days of mindfulness intervention, showed a positive outcome measured by the established scales of anxiety, happiness, and information processing. Psychometric or Prakriti wise analysis revealed that subject with “Pitta” constitution exposed to high altitude and advance meditation showed changes in more parameters than “Vatta” or “Kapha” Constitution. Conclusions Advance meditation in the high altitude zone confers biochemical and neuro‐cognitive benefits. Molecular studies may require to understand the role of hypoxic condition in improving the disease state.

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Section: Introductionmentioning

confidence: 99%

Effect of mindfulness meditation protocol in subjects with various psychometric characteristics at high altitude

et al. 2020

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“…The incidence of high altitude pulmonary oedema is related to the rate of ascent, the altitude reached, individual susceptibility and exertion, while cold increases pulmonary arterial pressure by means of sympathetic stimulation, which is an additional risk factor [1]. The annual incidence of hospital admission for HAPO in our Armed Forces is as low as 0.15 per thousand soldiers per year [2].…”

Section: Medical Problemsmentioning

confidence: 99%

The Highest Battlefield of the World : Medical Problems and Solutions

Jindal¹

2009

Medical Journal Armed Forces India

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The Indian Armed Forces Medical Services has been engaged in providing medical to the soldiers serving on Siachen Glacier for the last 25 years. This paper attempts to highlight the medical problems faced by troops on the world's highest battlefield as perceived by a medical officer located on the forward most medical echelon on Siachen Glacier. The medical problems on the glacier include high altitude pulmonary oedema, acute mountain sickness, frost bite chilblains, hypothermia, snow blindness, injury non enemy action due to avalanches, crevasses and fires, carbon monoxide poisoning and problems in disposal of nightsoil.

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“…Although, till date the pathogenesis of beverages to combat various high-altitude sicknesses this disease is poorly understood thus drug development process has been overlooked as well. Kapoor et al (2004) reported use of some drugs for the treatment of a few categories of HAS, mainly acute mountain sickness (AMS) and high-altitude pulmonary edema. To the best of our knowledge, natural products were rarely used for the docking of proteins cumulatively associated to HAS (Liang et al, 2018;Yeerjiang et al, 2023) and with traditional foods or beverages, this study is one of a kind.…”

Section: Introductionmentioning

confidence: 99%

In Silico Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

Majumder,

Chakraborty,

Ghosh

et al. 2023

Acta Universitatis Cibiniensis. Series E: Food Technology

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This in silico study has been designed to validate ethnomedicinal properties of some Himalayan fermented ethnic beverages against varied high-altitude sicknesses. Traditional beverages like tongba, chhyang, nigar and finger-millet raksi (supplemented with ethnomedicines like khokim and chimphing) were considered in this study which were sampled from villages situated in Singalila Ridge of the Himalayas. Seven major metabolites such as ethyl alpha-D-glucopyranoside; meranzin; auraptene; cis-vaccenic acid; cyclo(pro-gly); cyclo(leu-pro); and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one were investigated in silico to provide insights to their efficiency in alleviating major altitude illnesses (pulmonary edema and hypoxia); high-altitude respiratory infections; pain or inflammation; cardiovascular problems; gastrointestinal diseases and disorders; and high-altitude neurological diseases and disorders. Computational tools such as Molinspiration Chemoinformatics, SwissADME, Molsoft program and vNN-ADMET were employed to evaluate physicochemical properties, pharmacokinetics and ADMET parameters. Binding affinities were computed using Auto Dock Tools. In silico pharmacokinetics and ADMET revealed bioactivity potentials of selected metabolites which are associated to treat high-altitude sickness. A total of 175 combinations of receptor-ligand docking interactions were considered out of which 141 combinations exhibited a binding energy score of ≤ -5 and 29 combinations scored ≤ -7. Outcome of this computational research affirm the effectiveness of high-altitude’s traditional drinks in healing high-altitudinal stresses.

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Treatment of Acute Mountain Sickness and High Altitude Pulmonary Oedema

Cited by 10 publications

References 13 publications

Effect of mindfulness meditation protocol in subjects with various psychometric characteristics at high altitude

Effect of mindfulness meditation protocol in subjects with various psychometric characteristics at high altitude

The Highest Battlefield of the World : Medical Problems and Solutions

In Silico Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

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