Treatment of adolescent depression: what we have come to know

Vitiello, Benedetto

doi:10.1002/da.20572

Cited by 19 publications

(8 citation statements)

References 16 publications

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“…Furthermore, adolescents suffering from depression have a 40% chance of experiencing a recurrent episode later in life (10). When adolescent depression is left untreated, it can persist into adulthood and significantly increase the risk of developing other psychopathologies (11). However, it is important to note that the use of pharmacological antidepressants, such as selective serotonine reuptake inhibitors in adolescents has become surrounded by controversy, especially because the use of these drugs in adolescents has been associated with suicidality (suicidal thoughts, ideation or actions) during the first weeks of treatment (12).…”

Section: Depression In Adolescentsmentioning

confidence: 99%

Sex Differences in Adolescent Depression: Do Sex Hormones Determine Vulnerability?

Naninck

Lucassen

Bakker

2011

Journal of Neuroendocrinology

127

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Depression is one of the most common, costly and severe psychopathologies worldwide. Its incidence, however, differs significantly between the sexes, and depression rates in women are twice those of men. Interestingly, this sex difference emerges during adolescence. Although the adolescent period is characterised by major physical and behavioural transformations, it is unclear why the incidence of depression increases so dramatically in girls during this otherwise generally healthy developmental period. Although psychological and environmental factors are also involved, we discuss the neuroendocrinological factors determining adolescent vulnerability to depression. In particular, we address the role of sex steroids in mood regulation, hypothalamic‐pituitary‐adrenal axis maturation and sexual differentiation of the brain, with a focus on hippocampal plasticity.

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Section: Depression In Adolescentsmentioning

confidence: 99%

Sex Differences in Adolescent Depression: Do Sex Hormones Determine Vulnerability?

Naninck

Lucassen

Bakker

2011

Journal of Neuroendocrinology

127

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“…Research supports the use of pharmacotherapy, CBT, or IPT for the treatment of adolescent depression. Although these treatments are effective for many adolescents, approximately one-third of adolescents remain depressed following treatment, and a number of adolescents experience a relapse in later adolescence or adulthood 103. This suggests the need for further research to enhance existing treatment approaches, to develop and study novel treatments for adolescent depression, and to examine the appropriateness of depression interventions for various ethnic populations.…”

Section: Resultsmentioning

confidence: 99%

Screening and managing depression in adolescents

Young

Miller

Khan

2010

AHMT

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Approximately 10%–15% of adolescents will experience a major depressive episode. The risk factors associated with depression in adolescence include a family history of depression, being female, subthreshold depression, having a nonaffective disorder, negative cognitions, interpersonal conflict, low social support, and stressful life events. Despite the availability of measures to identify depressed adolescents and efficacious interventions to treat these adolescents, a large number of depressed adolescents go undetected and untreated. This review describes several screening measures that can be used to identify adolescents with elevated depression symptoms who would benefit from a comprehensive diagnostic evaluation. If an adolescent is diagnosed with a depressive disorder, there are several efficacious treatment options, including pharmacotherapy, cognitive behavior therapy, and interpersonal psychotherapy. The research supporting each of these approaches is outlined, and recommendations are made to help health professionals determine the appropriate course of treatment. Although existing treatments are effective for many depressed adolescents, approximately one-third of adolescents remain depressed following treatment. Continuing research is needed to enhance the efficacy of existing treatments for adolescent depression and to develop and study novel treatment approaches.

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“…Evidence of the role SSRIs play in suicidality outcomes in adults and children continues to be discussed given varied findings see e.g. (34,35,57,58), and the call for more pediatric research has been made to better understand the multiple pathways that mediate treatment emergent suicidality (59). Future studies need to include prospective data on both depressive symptoms scale and measures of self-harm as well as functional outcome over time to accurately assess SSRI response and the risk benefit ratio.…”

Section: Ssrismentioning

confidence: 95%

The Cochrane library and the treatment of major depression in children and youth: an overview of reviews

Zinck

Bagnell

Bond

et al. 2009

Evid.‐Based Child Health

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Background: Major depression (MDD) in children and adolescents is a mood disorder that has up to 25% lifetime prevalence by the end of adolescence. Pharmacological and nonpharmacological treatments are recommended to reduce symptoms, increase psychosocial functioning, and prevent relapse. Traditionally, decisions for these treatments were made based on reported effects for adults, but a body of pediatric-based evidence is now emerging to inform treatment decisions. Objectives:To synthesize the evidence currently in the Cochrane Library Database of Systematic Reviews (CDSR) related to the question: 'In children and youth with diagnosed major depression, do pharmacologic or nonpharmacologic treatments improve symptom response, response rates, functional capacity, adherence and persistence, and decrease cost and adverse events?'.Methods: CDSR was searched using the term 'depression' in the title for all systematic reviews examining pharmacologic and nonpharmacologic interventions for the treatment of depression in children ≤18 years. Data were extracted and entered into tables; data were synthesized using qualitative and quantitative methods. Main Results:Of the studies included in the CDSR, there was no significant improvement in treatment outcomes in depressed children and adolescents treated with pharmacological (tricyclic antidepressant [TCA] or selective serotonin reuptake inhibitor [SSRI]) or nonpharmacological (exercise) interventions.

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Treatment of adolescent depression: what we have come to know

Cited by 19 publications

References 16 publications

Sex Differences in Adolescent Depression: Do Sex Hormones Determine Vulnerability?

Sex Differences in Adolescent Depression: Do Sex Hormones Determine Vulnerability?

Screening and managing depression in adolescents

The Cochrane library and the treatment of major depression in children and youth: an overview of reviews

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