Treatment of advanced, metastatic soft tissue sarcoma: latest evidence and clinical considerations

In, Gino K; Hu, James; Tseng, William W.

doi:10.1177/1758834017712963

Cited by 81 publications

(75 citation statements)

References 160 publications

(240 reference statements)

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“…In general, doxorubicin-based regimens are recommended for the treatment of soft tissue sarcomas [9]. In addition, several cytotoxic agents were studied and reported to be useful for soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

A Case of Unresectable Pulmonary Artery Intimal Sarcoma with Prolonged Survival by Chemotherapy

Noguchi¹,

Gomi²,

Fukushima³

et al. 2019

Case Rep Oncol

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Pulmonary artery intimal sarcoma is a rare malignant tumor. Due to its low prevalence, little is known about efficacious systemic chemotherapies in cases where the tumors are unresectable or metastatic. In addition, the location of the disease can contribute to poor survival regardless of the response to therapy, as the tumor’s position can cause pulmonary artery hypertension either rapidly or chronically. We encountered a case of unresectable pulmonary artery intimal sarcoma with lung metastases. Treatment with several cytotoxic agents resulted in prolonged survival of 14.2 months. Here, we report the clinical course of this case and present a review of the relevant literature.

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Section: Discussionmentioning

confidence: 99%

A Case of Unresectable Pulmonary Artery Intimal Sarcoma with Prolonged Survival by Chemotherapy

Noguchi¹,

Gomi²,

Fukushima³

et al. 2019

Case Rep Oncol

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“…SW982 cells (4 × 10 6 cells in 50 µL PBS and 50 µL Matrigel matrix) were subcutaneously inoculated into nude mice to form tumor xenografts. When tumor size reached 120-180 mm 3 , mice were randomly assigned into two groups (n = 3 for each group), saline and epi-1 (250 µg in 100 µL saline). Saline or epi-1 were administered by intratumor injection once every two days for a total of seven injections.…”

Section: Human Synovial Sarcoma Xenograft Nude Mice Modelmentioning

confidence: 99%

“…Currently, standard therapeutic approaches for local tumors include surgical excision combined with radiotherapy and/or (neo)adjuvant chemotherapy. Anthracycline-based regimes are the first-line therapy [3,4]. Second-line chemotherapeutic agents for synovial sarcoma include Pazopanib, Trabectedin, and Eribulin [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells

Horng

et al. 2020

IJMS

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Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was identified from orange-spotted grouper (Epinephelus coioides), exhibits multiple biological effects, including bactericidal, immunomodulatory, and anticancer activities. However, the cytotoxic effects and mechanisms of epi-1 on human synovial sarcoma cells are still unclear. In this study, we report that epi-1 exhibits prominent antisynovial sarcoma activity in vitro and in a human SW982 synovial sarcoma xenograft model. Furthermore, we determined that calcium overload-induced calpain activation and subsequent oxidative stress and mitochondrial dysfunction are required for epi-1-mediated cytotoxicity. Interestingly, reactive oxygen species (ROS)-mediated activation of extracellular signal-regulated kinase (ERK) plays a protective role against epi-1-induced cytotoxicity. Our results provide insight into the molecular mechanisms underlying epi-1-induced cell death in human SW982 cells.

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“…head, neck or abdomen) and in these cases, chemotherapy is administered as first-line treatment [4]. Doxorubicin represents the standardof-care for sarcomas with a response rate of 12-30% [5]. Doxorubicin may be combined with dacarbazine or other agents, however these combination treatments typically do not increase the survival benefit compared to the monotherapy [6].…”

Section: Introductionmentioning

confidence: 99%

The immunocytokine L19-TNF eradicates Sarcomas in combination with Chemotherapy agents or with immune check-point inhibitors

Corbellari

Villa

Neri

et al. 2019

Preprint

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AbstractAntibody-cytokine fusion proteins (also called “immunocytokines”) represent an emerging class of biopharmaceutical products, which are being considered for cancer immunotherapy. When used as single agents, pro-inflammatory immunocytokines are rarely capable of induce complete and durable cancer regression in mouse models and in patients. However, the combination treatment with conventional chemotherapy or with other immune-stimulatory agents typically increases the therapeutic efficacy of immunocytokines.In this article, we describe combination treatments of a tumor-targeting antibody-cytokine fusion protein based on the L19 antibody (specific to a splice isoform of fibronectin) fused to murine tumor necrosis factor (TNF) with standard chemotherapy (dacarbazine, trabectedin or melphalan) or with an immune check-point inhibitor (anti-PD-1) in a BALB/c derived immunocompetent murine model of sarcoma (WEHI-164).All combination treatments led to improved tumor remission compared to single agent treatments, suggesting that these combination partners may be suitable for further clinical development in sarcoma patients.

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Treatment of advanced, metastatic soft tissue sarcoma: latest evidence and clinical considerations

Cited by 81 publications

References 160 publications

A Case of Unresectable Pulmonary Artery Intimal Sarcoma with Prolonged Survival by Chemotherapy

A Case of Unresectable Pulmonary Artery Intimal Sarcoma with Prolonged Survival by Chemotherapy

Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells

The immunocytokine L19-TNF eradicates Sarcomas in combination with Chemotherapy agents or with immune check-point inhibitors

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