Treatment of age-related macular degeneration

Stokkermans, Thomas J.

doi:10.1016/s0953-4431(99)00043-0

Cited by 11 publications

(11 citation statements)

References 185 publications

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“…However, it is expensive and studies show that benefit is limited to eyes with classical patterns of CNV, which represent a minority of cases (4). Radiation therapy for CNV has a less favorable outcome with considerable side-effects (5). Submacular surgery for removal of CNV has a disappointing result in type I membrane (Sub RPE type), which is typical of age related macular degeneration (6).…”

Section: Introductionmentioning

confidence: 99%

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Preventive Versus Treatment Effect of Ag3340, a Potent Matrix Metalloproteinase Inhibitor in a Rat Model of Choroidal Neovascularization

Bradey

Cheng

Bartsch

et al. 2004

Journal of Ocular Pharmacology and Therapeutics

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Purpose: AG3340 (prinomastat) is a nonpeptidic, small-molecular-weight, synthetic matrix metalloproteinase inhibitor (MMPI) with selective inhibitory action of MMP-2, MMP-9, MMP-3, and MT-MMP1. We evaluated AG3340 injected intravitreally to treat choroidal neovascularization in a laser induced rat CNV model. Methods: In the pretreatment group, the drug was injected the same day after induction of choroidal neovascularization by diode laser. In the treatment group, the drug was injected 2 weeks after induction of choroidal neovascularization (CNV). Fluorescein and indocyanine green angiography were performed to evaluate CNV. ERG recordings and histology were performed to assess toxicity and the CNV lesions. Results: When used at the time of CNV induction, 62.8% of lesions in control versus 22.8% of the laser lesions in treated eyes developed CNV (p < 0.0001). The invading fibrovascular complex was thicker in the control eyes than that in the treated eyes. No signs of toxicity were detected. When used to treat established CNV, the percentage of leakage in treated and control eyes were 54.1% and 58.9% respectively (p > 0.05). Prinomastat was effective when given at the time of induction of CNV in the rat model. Administration of prinomastat 2 weeks after laser induction did not show efficacy. Conclusion: Prinomastat was active in the earliest stages of experimental CNV. It might be best used in combination with photodynamic therapy to inhibit recurrence of CNV from temporarily closed new vessels.

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Section: Introductionmentioning

confidence: 99%

“…Submacular surgery for removal of CNV has a disappointing result in type I membrane (Sub RPE type), which is typical of age related macular degeneration (6). Macular translocation surgery for CNV is still evolving with variable results and of high-risk complications (5).…”

Section: Introductionmentioning

confidence: 99%

Preventive Versus Treatment Effect of Ag3340, a Potent Matrix Metalloproteinase Inhibitor in a Rat Model of Choroidal Neovascularization

Bradey

Cheng

Bartsch

et al. 2004

Journal of Ocular Pharmacology and Therapeutics

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“…The role of the care providers consists in administration, evaluation, and monitoring of the patient for acute drug reactions during the procedure or patient education. It is noteworthy that the implementation of formalized, proactive interdisciplinary approaches in treating other diseases, like chronic kidney disease, was found to have a positive impact on patients' well-being [49,50].…”

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Kocki¹,

Czarczyńska-Goślińska²,

Kocka³

et al. 2017

Photomedicine - Advances in Clinical Practice

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Background: The modern treatment is based on wide cooperation between diverse representatives of medical professions. The photodynamic therapy is a noninvasive method of treatment both neoplastic diseases and miscellaneous noncancerous illnesses. It is complementary and competitive in some way to various traditional treatment techniques, including chemotherapy, radiotherapy, and surgery. This review emphasizes the significance of collaboration between specialists engaged in research, development, and practical use of photodynamic therapy.Methods: A literature search of electronic bibliographic databases and scientific publishers was performed. The relevant literature was analyzed to identify articles on the involvement of nurses, pharmacists, physicians, and other representatives in photodynamic therapy treatment.Results: In the photodynamic therapy, the overall success is not only dependent of a single unit. Coordinated actions of representatives possessing expertise in various fields of medical, and natural sciences are necessary both during joint research, development, and during the course of the photodynamic therapy treatment in clinics. Conclusions:The effective interaction between professionals and the division of responsibilities at different stages of therapy can guarantee the successful treatment. During therapy, the most important role belongs to the patient who is responsible for acting in accordance with schedules elaborated by physicians, nurses, and pharmacists.

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“…Current treatments attempt to stabilize the evolution of AMD, 6,7 but typically cannot restore full visual function. Indeed, there are several forms of AMD, not all of which are susceptible to the same treatments.…”

Section: Introductionmentioning

confidence: 99%

“…Visual performance on tasks necessary for daily living, such as reading, 3 writing and recognition of faces and objects, 4 is often severely impaired; in addition, the risk for falls is significantly increased. 5 Current treatments attempt to stabilize the evolution of AMD, 6,7 but typically cannot restore full visual function. Indeed, there are several forms of AMD, not all of which are susceptible to the same treatments.…”

Section: Introductionmentioning

confidence: 99%

Influence of background on image recognition in normal vision and age‐related macular degeneration

Bordier

Petra

Dauxerre

et al. 2011

Ophthalmic Physiologic Optic

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Treatment of age-related macular degeneration

Cited by 11 publications

References 185 publications

Preventive Versus Treatment Effect of Ag3340, a Potent Matrix Metalloproteinase Inhibitor in a Rat Model of Choroidal Neovascularization

Preventive Versus Treatment Effect of Ag3340, a Potent Matrix Metalloproteinase Inhibitor in a Rat Model of Choroidal Neovascularization

Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Influence of background on image recognition in normal vision and age‐related macular degeneration

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