Treatment of Agitation in Patients with Dementia

A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia

“…The direct and superior effect of risperidone on aggression compared to haloperidol might be attributed to its serotonin-blocking effects 33 because dysfunctions in the serotonin system have been implicated in aggressive behavior in both animals and humans. 34 Risperidone was well tolerated in these elderly patients with dementia. Particularly, the severity of EPS with risperidone was not significantly different from that with placebo, whereas haloperidol was associated with significantly more severe EPS.…”

Dementia, pain, depression, behavioral disturbances, and ADLs: toward a comprehensive conceptualization of quality of life in long‐term care

“…The resident's resistance to ADLs is often attributed to depression or dysfunctional behaviors associated with dementia. These conditions are often treated with psychopharmacological interventions and cognitive-behavioral therapy (Hay et al, 1998;Lichtenberg et al, 1998;Mintzer et al, 1998;Coleman and Fox, 2002). …”

The Effect of Risperidone on Nursing Burden Associated with Caring for Patients with Dementia

“…The BPSD can be disruptive and burdensome in a longterm care setting, interfering directly with care and nursing staff response to patients. [1][2][3][4] Caring for a high proportion of cognitively impaired patients was associated with high nursing assistant stress. 5 Implementing interventions for residents with dementia can take extensive staff time.…”