“…The antidotes benzylpenicillin, ceftazidime, Nacetyl-cysteine (NAC), rifamycin, and silibinin have been advocated by some [26,34,36,88,[110][111][112], and questioned by others [113,114]. Of these, silibinin and NAC show the most promise [32,34,111,115]. Magdalan [34] performed cell culture studies and found that hepatocytes poisoned with alpha-amanitin and simultaneously treated with NAC or silibinin showed less evidence of lipid peroxidation than poisoned hepatocytes simultaneously treated with benzylpenicillin or without an antidote treatment.…”