Treatment of Anaerobically Infected Pressure Sores With Topical Metronidazole

Jones, Philip H.; Willis, A. T.; Ferguson, I. R.

doi:10.1016/s0140-6736(78)90654-2

Cited by 27 publications

(16 citation statements)

References 4 publications

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“…Many of the organisms in these mixtures were potential patbogens, but there is some evidence that the anaerobes are the more significant pathogens. Willis et al (1975Willis et al ( , 1976Willis et al ( , 1977 showed that treatment of the anaerobic component of infections related to the appendix, colon, rectum and female genital tract with metronidazole controlled the infections, and Jones, Willis & Ferguson (1978) obtained healing of infected decubitus ulcers with topical metronidazole. However, the facultative and aerobic species in the mixtures should not be ignored; there may be synergy between components of the mixed flora (Tally & Gorbach, 1979) …”

Section: Discussionmentioning

confidence: 99%

The identification of gram-negative anaerobic bacilli isolated from clinical infections

Duerden

1980

J. Hyg.

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SUMMARYGram-negative anaerobic bacilli isolated from specimens submitted to the routine diagnostic bacteriology laboratory and regarded as significant pathogens were identified by conventional bacteriological tests; 399 strains isolated from 356 specimens submitted from 332 patients were studied and most were readily identified by the results of a combined set of morphological, biochemical, tolerance and antibiotic disk resistance tests. B. fragilis has particular pathogenic potential and was the commonest species isolated, accounting for > 50 % of strains. The next commonest was B. asaccharolyticus with 55 strains, and 16 other species or groups were represented by smaller numbers. Many (68 %) were from infections related to the gastro-intestinal tract, but there were significant numbers from infections of the male and female genito-urinary tracts, the head, neck and central nervous system and from a variety of soft tissue infections. Most infections were mixed, and a pure culture of a Bacteroides sp. was obtained from only 26 % of infections; two or more strains of Bacteroides were recovered from 55 infections. The specific identification of Bacteroides may help the bacteriologist to judge the significance of laboratory findings, influence the patient's management and prognosis and help determine the source of infection.

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Section: Discussionmentioning

confidence: 99%

The identification of gram-negative anaerobic bacilli isolated from clinical infections

Duerden

1980

J. Hyg.

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“…Surveys of incidences among hospitalized patients have given prevalence figures of 4 to 11 per cent, but the definitions of a decubitus ulcer used by these surveys were not consistent, and some included patients in whom the skin was not broken 2–5 . A number of studies have shown rapid healing of decubitus ulcers with various topical regimens, 6–8 but few were controlled trials 9,10 …”

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confidence: 99%

A Randomized Trial of Cadexomer Iodine in Decubitus Ulcers

Moberg

Hoffman²,

Grennert³

et al. 1983

J American Geriatrics Society

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Thirty-four patients with decubitus ulcers were studied in a randomized trial to compare topical cadexomer iodine with the standard decubitus ulcer treatments used in the participating hospitals. There was a significant reduction of ulcer area with both treatments within three weeks; however, eight of 16 patients treated with cadexomer iodine had a reduction of ulcer area of more than 50 per cent, compared with one of 18 patients treated with the standard treatment (P less than 0.01). Twenty-seven patients continued the same treatment for five more weeks, during which time six in the cadexomer iodine group healed, compared with one in the standard treatment group (P less than 0.05). Cadexomer iodine was superior to the standard treatment in removing pus and debris from the ulcer surface and in reducing pain at the ulcer site. It was found to be easy both to apply and to remove from the ulcers and did not stain skin or clothing. Transient smarting during the first hour after application was reported by three patients, and one patient complained of skin irritation. The results show that cadexomer iodine applied daily has a debriding effect on decubitus ulcers and accelerates healing.

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“…In 1978 (7) , one study reported (in the form of a letter to the editor) the putrid odor that some pressure ulcers exuded and other cases in which patients progressed to sepsis caused by anaerobic bacteria. The authors describe that from previous publications on the successful treatment of patients with sepsis caused by anaerobic bacteria through systemic metronidazole, they began to suggest its topical use on infected wounds.…”

Section: Discussionmentioning

confidence: 99%

Controlling wound odor with metronidazole: a systematic review

Castro

Santos

2015

Rev. esc. enferm. USP

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Objective: Verifying the evidence of therapeutic efficacy in the topical application of metronidazole for controlling wound odor. Methods: A systematic literature review, according to the Cochrane Collaboration recommendations. Results: 329 articles were identified in the Cochrane, LILACS, SciELO, CINAHL and PubMed databases, with 14 of them being included in the final sample. Two of the studies were double-blind randomized clinical trial studies. Conclusion: The actual effectiveness of metronidazole in controlling wound odor cannot yet be evidenced due to the absence of strong evidence from studies on the subject, despite clinical practice recommending its benefits.

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Treatment of Anaerobically Infected Pressure Sores With Topical Metronidazole

Cited by 27 publications

References 4 publications

The identification of gram-negative anaerobic bacilli isolated from clinical infections

The identification of gram-negative anaerobic bacilli isolated from clinical infections

A Randomized Trial of Cadexomer Iodine in Decubitus Ulcers

Controlling wound odor with metronidazole: a systematic review

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