Treatment of antibiotic-resistant bacteria by encapsulation of ZnO nanoparticles in an alginate biopolymer: Insights into treatment mechanisms

Baek, Soyoung; Joo, Sun Hyung; Toborek, Michał

doi:10.1016/j.jhazmat.2019.03.072

Cited by 54 publications

(23 citation statements)

References 55 publications

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“…The bactericidal activity of various concentrations of ZnO NPs (100, 200, 300, and 400 mg mL -1 ) was evaluated. The inhibitory zones created by the ZnO NPs showed that their activities were concentrationdependent, i.e., higher concentrations of ZnO NPs lead to more active sites, larger surface areas, and higher bactericidal activities [51][52][53].…”

Section: Antimicrobial Activity Of Zno Npsmentioning

confidence: 99%

Synthesis of ZnO Nanoparticles with Antibacterial Properties Using Terminalia catappa Leaf Extract

2022

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In order to develop alternative drugs against resistant pathogens, capped ZnO nanoparticles (NPs) were prepared using Terminalia catappa leaf extract. By changes in pH and aging time, cauliflower-like, sheet-like, and hierarchical morphologies for ZnO NPs were obtained. Their antibacterial activities against Staphylococcus aureus and Escherichia coli were investigated. The results demonstrated that the green synthesized ZnO NPs exhibit higher antibacterial activity than chemically prepared ZnO NPs. The antibacterial activity of hierarchical ZnO NPs was greater than that of the other morphologies, which was attributed to the higher oxygen vacancy in ZnO NPs leading to enhanced reactive oxygen species (ROS) generation. The mechanism of the formation of ZnO nanocrystals was also discussed.

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Section: Antimicrobial Activity Of Zno Npsmentioning

confidence: 99%

Synthesis of ZnO Nanoparticles with Antibacterial Properties Using Terminalia catappa Leaf Extract

2022

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“…Gelation of alginate is initiated by increasing the solubility of calcium source and/or lowering the pH of the emulsion from 7.5 to 6.5, where calcium ions begin to migrate from the inner droplets to the outer part as shown in Equations (2) and (3) [ 67 , 68 ]. Internal gelation produces symmetrical micro/nanospheres with large pores and low matrix density compared to that prepared by external gelation [ 60 , 61 ]. 2H + + CaCO 3 → Ca 2+ + CO 2 Ca 2+ + 2Na + Alg − → Ca 2+ (Alg − ) 2 + 2Na + …”

Section: Alginate Nanoparticles Preparation Methodsmentioning

confidence: 99%

“…On top of that, the application of alginate nanoparticles in cancer treatment has gained wide attention due to the ability to deliver anti-cancer therapeutics in sufficient manner at target site, promoting the bioavailability as well as reducing drug dosage and its side effects to the normal tissues [ 58 , 59 ]. Alginate nanoparticles have been also used for targeted antibiotic delivery applications without inducing resistant strains of bacteria [ 60 , 61 ]. The applications and fields that utilized alginate nanoparticles grew proportionally due to their useful properties and simple synthesis methods.…”

Section: Alginate Nanoparticlesmentioning

confidence: 99%

Alginate Nanoformulation: Influence of Process and Selected Variables

2020

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Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance, as well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and biomedical applications as a matrix material of nanocarriers due to its inherent biological properties, including good biocompatibility and biodegradability. Various techniques have been adopted to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and cost-effective properties. This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the main processing and formulation parameters on alginate nanoparticles are also summarized.

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“…During the last five years, different research groups have sought to use natural polymers in combination with ZnO NPs as a possible treatment against multidrug-resistant bacteria [ 141 , 190 , 191 , 192 , 193 ]. A group of researchers evaluated the antibacterial effects of NPs of chitosan, ZnO alone, and a combination of chitosan and ZnO against MDR and wild-type strains.…”

Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections.

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Treatment of antibiotic-resistant bacteria by encapsulation of ZnO nanoparticles in an alginate biopolymer: Insights into treatment mechanisms

Cited by 54 publications

References 55 publications

Synthesis of ZnO Nanoparticles with Antibacterial Properties Using Terminalia catappa Leaf Extract

Synthesis of ZnO Nanoparticles with Antibacterial Properties Using Terminalia catappa Leaf Extract

Alginate Nanoformulation: Influence of Process and Selected Variables

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

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