Tetracycline antibiotics are widely used in human medical treatment, control of animal disease, and agricultural feed because of their broad spectrum of action, high efficiency, and low cost. The excessive use of antibiotics and arbitrary discharge of antibiotic wastewater have become increasingly serious problems, and the current sewage-treatment process is not ideal for treating water contaminated with tetracycline antibiotics, leading to increasingly prominent antibiotic pollution in water and the imminent need for its removal. In order to understand the necessity of removing tetracycline antibiotics from the water environment, this paper first expounds on their source, harms, and pollution status in oceans and in surface water, groundwater, wastewater, and drinking water. It next introduces the research status of conventional treatment methods such as adsorption methods, biological methods, and physical and chemical methods, then introduces new treatment methods such as advanced oxidation methods and comprehensive treatment technology in sewage plants. The degradation effects, mechanisms of action, and challenges of these methods were summarized. The advantages and disadvantages of each treatment technology are compared. Finally, potential future processing technologies are discussed.