2018
DOI: 10.1111/jocd.12552
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Treatment of auricular keloids by triple combination therapy: Surgical excision, platelet‐rich plasma, and cryosurgery

Abstract: This combination therapy was effective for treatment of auricular keloids, with a low recurrence rate and a favorable cosmetic outcome. Therapy was well tolerated and without significant side effects.

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Cited by 27 publications
(26 citation statements)
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“…Omar [34] Intraoperative treatment 1 Stopped freezing when impedance meter reached 1000 kX, combination therapy with excision and platelet-rich plasma with these results, although 7/59 exhibited some degree of hyperpigmentation [40]. Additional work to detail the mechanism of action of this efficacious treatment found that keloid fibroblasts treated with PDL had a statistically different cell cycle phase distribution than control fibroblasts, with the majority of treated fibroblasts being in G0 and G1 versus control fibroblasts being in proliferative phases [41].…”
Section: Azzam Andmentioning
confidence: 99%
See 1 more Smart Citation
“…Omar [34] Intraoperative treatment 1 Stopped freezing when impedance meter reached 1000 kX, combination therapy with excision and platelet-rich plasma with these results, although 7/59 exhibited some degree of hyperpigmentation [40]. Additional work to detail the mechanism of action of this efficacious treatment found that keloid fibroblasts treated with PDL had a statistically different cell cycle phase distribution than control fibroblasts, with the majority of treated fibroblasts being in G0 and G1 versus control fibroblasts being in proliferative phases [41].…”
Section: Azzam Andmentioning
confidence: 99%
“…Combination therapy of excision, handheld cryotherapy, and platelet-rich plasma found an average Vancouver Scar Scale (VSS) improvement of 84%, although 26% of lesions failed to flatten by more than 30%. One hundred percent of patients experienced hyperpigmentation [ 34 ]. In sum, while cryotherapy is known to be painful, intralesional cryotherapy is efficacious, especially with newer lesions [ 30 ].…”
Section: Cryotherapymentioning
confidence: 99%
“…Actually, the monotherapeutic use of intralesional TAC in keloids treatment has been shown to be effective but it might induce more side effects in the form of hypopigmentation, mixed pigmentation, fat atrophy, telangiectasias, necrosis and ulcerations [4,23,24].…”
Section: Discussionmentioning
confidence: 99%
“…A number of growth factors released by the activated platelets promote wound healing, angiogenesis, collagen remodeling, and tissue restoration. To date, PRP is used in a wide spectrum of skin condition for anti‐inflammatory, healing, and cosmetic purposes 59 . Improvement of wound healing with less keloid recurrences was noted after PRP injection after keloid excision in a number of studies (Table 1).…”
Section: Emerging Treatmentsmentioning
confidence: 99%
“…Improvement of wound healing with less keloid recurrences was noted after PRP injection after keloid excision in a number of studies (Table 1). 25,59–62 …”
Section: Emerging Treatmentsmentioning
confidence: 99%