Treatment of bacterial infections in children with sultamicillin

Scholz, H; Märker, X; Rockstroh, T

doi:10.1016/s0924-8579(96)80007-0

International Journal of Antimicrobial Agents

1996

DOI: 10.1016/s0924-8579(96)80007-0

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Treatment of bacterial infections in children with sultamicillin

H Scholz¹,

X Märker²,

T Rockstroh³

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Cited by 2 publications

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Use of Ampicillin/Sulbactam and Sultamicillin in Pediatric Infections: A Re-Evaluation

Dajani

2001

J Int Med Res

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Ampicillin/sulbactam is an effective solution to the emergence of beta-lactamase-mediated resistance among common pediatric pathogens, and is a widely recognized treatment option for a variety of pediatric infections. Recent antimicrobial surveillance data confirm the continued susceptibility of many Gram-positive and Gram-negative aerobes and anaerobes to ampicillin/sulbactam. Pharmacokinetic studies have demonstrated high drug concentrations at a variety of infection sites, including cerebrospinal fluid and bone. Furthermore, clinical studies have shown that ampicillin/sulbactam, administered intravenously, intramuscularly or orally (as the mutual prodrug sultamicillin), is clinically and bacteriologically effective against upper and lower respiratory tract infections, urinary tract infections, skin, bone and soft-tissue infections, and meningitis, and provides effective surgical prophylaxis. Sultamicillin has an excellent tolerability profile, which is associated with a low rate of treatment discontinuation. Accordingly, ampicillin/sulbactam and sultamicillin should be considered first-choice options for the management of a variety of pediatric infections.

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Use of Ampicillin/Sulbactam and Sultamicillin in Pediatric Infections: A Re-Evaluation

Dajani

2001

J Int Med Res

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Beta-Lactam/Beta-Lactamase Inhibitor Combinations in Empiric Management of Pediatric Infections

Adam

2002

J Int Med Res

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Beta-lactam antibiotics have long played a central role in the management of pediatric infections. However, widespread beta-lactam resistance among community- and hospital-acquired pathogens, mainly due to beta-lactamase production, has reduced the usefulness of these trusted and well-tolerated agents. Many regions have reported an increase in beta-lactamase-mediated resistance to cephalosporins and carbapenems as well as penicillins among clinically important Gram-positive and Gram-negative aerobes and anaerobes. For some pathogens such as Moraxella catarrhalis, Klebsiella species and Pseudomonas aeruginosa, virtually all strains worldwide are beta-lactamase producers. The development of beta-lactamase inhibitors for co-administration with a number of established beta-lactam agents has restored their usefulness in pediatric patients. The combination of ampicillin plus sulbactam has broad anti-aerobic and anti-anaerobic activity in vitro and achieves high concentrations in many body tissues and fluids. The availability of a mutual oral prodrug, sultamicillin, has enabled the development of an oral formulation. Excellent clinical response and bacterial eradication rates with ampicillin/sulbactam and sultamicillin have been demonstrated for upper and lower respiratory tract infections, urinary tract infections, osteomyelitis, and meningitis in pediatric patients and neonates. Furthermore, many studies have demonstrated an excellent tolerability profile. Thus, ampicillin/sulbactam has an important role in the management of pediatric infections.

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Treatment of bacterial infections in children with sultamicillin

Cited by 2 publications

References 4 publications

Use of Ampicillin/Sulbactam and Sultamicillin in Pediatric Infections: A Re-Evaluation

Use of Ampicillin/Sulbactam and Sultamicillin in Pediatric Infections: A Re-Evaluation

Beta-Lactam/Beta-Lactamase Inhibitor Combinations in Empiric Management of Pediatric Infections

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