Treatment of basal-cell carcinoma: Comparison of radiotherapy and cryotherapy

Hall, Virginia L.; Leppard, Barbara; McGill, Janet B.; Kesseler, M.E.; White, John; Goodwin, Peter

doi:10.1016/s0009-9260(86)80161-1

Cited by 114 publications

(75 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RCTs comparing cryosurgery with a variety of other treatment modalities (MAL and ALA PDT, standard excision, and radiation therapy) have reported recurrence rates for cryosurgery ranging between 6.3% at 1 year to 39% after 2 years of followup. 41,[60][61][62] Cryosurgery may be considered for low-risk BCC when more effective therapies are contraindicated or impractical. 2 …”

Section: Cryosurgerymentioning

confidence: 99%

“…24,34,46,62,88,100,101 Several different types of radiotherapy can be used to treat BCC, including superficial radiation therapy, isotope-based brachytherapy (interstitial or topical contact), and external electron beam radiation. Primary or adjuvant radiation is an effective treatment option for selected patients with BCC, resulting in good tumor control and cosmesis, with the understanding that cure rates may be lower.…”

Section: Radiation Therapymentioning

confidence: 99%

“…Primary or adjuvant radiation is an effective treatment option for selected patients with BCC, resulting in good tumor control and cosmesis, with the understanding that cure rates may be lower. 23,34,46,62,88,100,101 One RCT demonstrated that in terms of long-term cosmesis, surgery is superior to radiotherapy for primary BCCs of the face smaller than 4 cm. 34 The radiation technique is modified depending on the site, size, shape, and depth of the tumor.…”

Section: Radiation Therapymentioning

confidence: 99%

See 2 more Smart Citations

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

328

219

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

show abstract

Section: Cryosurgerymentioning

confidence: 99%

Section: Radiation Therapymentioning

confidence: 99%

Section: Radiation Therapymentioning

confidence: 99%

See 1 more Smart Citation

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

328

219

View full text Add to dashboard Cite

show abstract

“…The superiority of RT over some other treatment modalities has been illustrated in data such as a randomized controlled trial comparing RT with cryotherapy. In patients with tumors mostly <2 cm, RT was found to have a reduced 2-year local failure rate (4 % in RT vs. 39 % in cryotherapy) [40]. PNI perineural invasion, Gy gray, post-op post-operative, LINAC linear accelerator a Dose-fractionation schedules using fraction sizes <4 Gy may reduce the risk of necrosis and ulceration b Only daily fraction sizes >6 Gy (p=0.0093) and treatment times <5 days (p=0.0053) were significantly associated with an increased risk of necrosis Radiotherapy is further a successful treatment modality in managing recurrent BCC following surgical excision.…”

Section: Radiotherapy Treatment Of Bccmentioning

confidence: 92%

Treatment of Non-Melanomatous Skin Cancer with Radiotherapy

et al. 2015

View full text Add to dashboard Cite

Non-melanomatous skin cancer (NMSC) is the leading cause of cancer in the United States. Treatment with surgical excision is considered the gold standard, but radiotherapy is an excellent alternative to surgical excision. Radiotherapy for NMSC takes many forms including a variety of external beam treatments as well as brachytherapy. Radiotherapy is indicated in a broad range of patients and is particularly useful in elderly patients who are poor surgical candidates or prefer not to have surgery. Radiotherapy is also employed in certain cases of recurrence and perineural invasion and when margin control is a concern. In addition to discussing standard techniques and indications for radiotherapy, this article will review specific considerations for radiotherapy in the treatment of basal cell carcinoma and squamous cell carcinoma. Finally, the article will examine new developments in the treatment of NMSC with radiotherapy including electronic brachytherapy and Helical TomoTherapy.

show abstract

“…Other Treatment Options BCC in patients in whom an operation is contraindicated, or tumors otherwise not suited for surgery can also be treated effectively with radiation therapy [47]. However, because of the carcinogenic long-term effects of radiation this procedure should be reserved for older patients.…”

Section: Therapeutic Standard Proceduresmentioning

confidence: 99%

Management of Epithelial Dermatologic Neoplasia

Kaufmann¹

1998

Oncol Res Treat

View full text Add to dashboard Cite

Treatment of basal-cell carcinoma: Comparison of radiotherapy and cryotherapy

Cited by 114 publications

References 3 publications

Guidelines of care for the management of basal cell carcinoma

Guidelines of care for the management of basal cell carcinoma

Treatment of Non-Melanomatous Skin Cancer with Radiotherapy

Management of Epithelial Dermatologic Neoplasia

Contact Info

Product

Resources

About