Treatment of Benign Prostatic Hyperplasia Using Transurethral Microwave Thermotherapy and Dilatation with Double-Balloon Catheter

Tsukada, Osamu; Murakami, Maki; Kosuge, Takashi; Yokoyama, Hiromi

doi:10.1089/end.2005.19.1016

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Use of double-cuff Foley catheters has been previously reported where the second cuff was placed in various positions for a variety of purposes. ese include secondary cuffs at the drainage tip to cushion the bladder wall [10,11], catheters with secondary cuffs for surgical management and manipulation [12,13], and catheters with secondary cuffs distal to the meatus for diagnostic purposes [14,15]. A double-cuff catheter capable of irrigating the external catheter shaft Step B: irrigation of the periurethral space with diluted Mueller Hinton broth wets the catheter shaft and incubation for 4 hours provides nutrients for biofilm to colonize transurethrally up to the bladder.…”

Section: Discussionmentioning

confidence: 99%

Pilot Ex Vivo and In Vitro Evaluation of a Novel Foley Catheter with Antimicrobial Periurethral Irrigation for Prevention of Extraluminal Biofilm Colonization Leading to Catheter-Associated Urinary Tract Infections (CAUTIs)

Vargas-Cruz

Rosenblatt

Reitzel

et al. 2019

BioMed Research International

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CAUTI remains a serious healthcare issue for incontinent patients whose urine drainage is managed by catheters. A novel double-balloon Foley catheter was developed which was capable of irrigating the extraluminal catheter surfaces within the periurethral space between the urethral-bladder junction and meatus. The catheter has a retention cuff that is inflated to secure the catheter in the bladder and a novel irrigation cuff proximal to the urethral-bladder junction capable of providing periurethral irrigation from the urethral-bladder junction to the meatus. Uniform periurethral irrigation was demonstrated in an ex vivo porcine model by adding a dye to the antimicrobial urethral irrigation solution. An in vitro biofilm colonization model was adapted to study the ability of periurethral irrigation with a newly developed antimicrobial combination consisting of polygalacturonic acid + caprylic acid (PG + CAP) to prevent axial colonization of the extraluminal urethral indwelling catheter shaft by common uropathogens. The extraluminal surface of control catheters that were not irrigated formed biofilms along the entire axial urethral tract after 24 hours. Significant (p<0.001) inhibition of colonization was seen against multidrug-resistant Pseudomonas aeruginosa (PA), carbapenem-resistant Escherichia coli (EC), and carbapenem-resistant Klebsiella pneumoniae (KB). For other common uropathogens including Candida albicans (CA), Proteus mirabilis (PR), and Enterococcus faecalis (EF), a first irrigation treatment completely inhibited colonization of half of the indwelling catheter closest to the bladder and a second treatment largely disinfected the remaining intraurethral portion of the catheter towards the meatus. The novel Foley catheter and PG + CAP antimicrobial irrigant prevented biofilm colonization in an in vitro CAUTI model and merits further testing in an in vivo CAUTI prevention model.

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