Treatment of Benign Prostatic Hyperplasia by Natural Drugs

Csikós, Eszter; Horváth, Adrienn; Ács, Kamilla; Papp, Nóra; Balázs, Viktória Lilla; Dolenc, Marija Sollner; Kenda, Maša; Glavač, Nina Kočevar; Nagy, Milan; Protti, Michele; Mercolini, Laura; Horváth, Györgyi; Farkas, Ágnes

doi:10.3390/molecules26237141

Cited by 66 publications

(55 citation statements)

References 206 publications

(271 reference statements)

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“…Although the etiology is not yet fully defined, some theories agree on the conversion of testosterone to dihydrotestosterone (DHT) by the enzyme 5-α-reductase, to later promote the production of growth factors. DHT has a high affinity for androgen receptors, thus pharmacological treatments have been based on the use of 1-α-adrenoreceptor antagonists and 5-α-reductase inhibitors [ 77 ]. However, side effects have been reported such as erectile dysfunction, loss of libido, and dizziness, particularly for 5-α-reductase inhibitor drugs.…”

Section: The Role Of Plants In Renal Pathophysiologymentioning

confidence: 99%

“…The daily administration of a tablet formulated with 350 mg of crude extract induced a significant decrease in residual urine volume and nocturia after 12 weeks of treatment. The mitigation of BPH symptoms was attributed to the phytosterols and fatty acids as the active molecules from the pumpkin seeds [ 76 , 77 ].…”

Section: The Role Of Plants In Renal Pathophysiologymentioning

confidence: 99%

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Nephroprotective Plants: A Review on the Use in Pre-Renal and Post-Renal Diseases

Tienda-Vázquez

Morreeuw

Sosa‐Hernández

et al. 2022

Plants

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Kidney diseases are expected to become the fifth leading cause of death by 2040. Several physiological failures classified as pre-, intra-, and post-renal factors induce kidney damage. Diabetes, liver pathologies, rhabdomyolysis, and intestinal microbiota have been identified as pre-renal factors, and lithiasis or blood clots in the ureters, prostate cancer, urethral obstructions, prostate elongation, and urinary tract infections are post-renal factors. Additionally, the nephrotoxicity of drugs has been highlighted as a crucial factor inducing kidney injuries. Due to the adverse effects of drugs, it is necessary to point to other alternatives to complement the treatment of these diseases, such as nephroprotective agents. Plants are a wide source of nephroprotective substances and can have beneficial effects in different levels of the physiological pathways which lead to kidney damage. In traditional medicines, plants are used as antioxidants, anti-inflammatories, diuretics, and anticancer agents, among other benefits. However, the mechanism of action of some plants empirically used remains unknown and scientific data are required to support their nephroprotective effects. The present work reviewed the plants with a beneficial effect on kidney diseases. The classification of nephroprotective plants according to the clinical definition of pre-renal, intrinsic, and post-renal factors is proposed to orient their use as complementary treatments.

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Section: The Role Of Plants In Renal Pathophysiologymentioning

confidence: 99%

Section: The Role Of Plants In Renal Pathophysiologymentioning

confidence: 99%

Nephroprotective Plants: A Review on the Use in Pre-Renal and Post-Renal Diseases

Tienda-Vázquez

Morreeuw

Sosa‐Hernández

et al. 2022

Plants

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show abstract

“…The commonest herbal preparation or phytochemical used in cited studies is Prostacare, a saw palmetto extract [ 19 ]. In contrast, pumpkin (Cucurbita pepo) is the most common phytochemical used in the management of BPH across the world [ 37 ].…”

Section: Reviewmentioning

confidence: 99%

A Scoping Review of the Management of Benign Prostate Hyperplasia in Africa

Zubair¹,

Davis²,

Balogun³

et al. 2022

Cureus

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Benign prostatic hyperplasia (BPH) is a non-malignant prostate gland enlargement of unknown cause that affects more than 50% of men over 60 and is the most common cause of bladder outlet obstruction and voiding symptoms. BPH is treated primarily with watchful waiting, phytotherapy (herbs), and medical or surgical options. In this study, we sought to examine the different management practices in African urological centers, outcomes of management, and complications. A literature search was conducted using PubMed, African Journal Online, and Google Scholar regarding the management of BPH from inception till date. Articles were selected based on their relevance to the management of benign prostatic enlargement in Africa. Results are reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. The studies included were conducted from 1997 to 2022. They were from eight different African countries (Nigeria, Kenya, Togo, Ethiopia, Egypt, South Africa, Ghana, and Congo), with Nigeria contributing the most with 10 studies. Exactly 2999 patients were included in the study. Seventy-three (73.49%) percent of these patients totaling 2204, underwent surgical management of BPH, 124 (4.13%) patients were treated with phytomedicines or herbs, and 684 (22.80%) patients were treated with medical therapy. The complications and outcomes were studied and collated. A total of 808 patients opted for non-surgical treatment for BPH in the included studies. In this group, 124 were treated using phytochemicals or natural herbs, and 648 were treated with standard prescription medications. While surgical treatment for benign prostatic enlargement is shifting towards minimally invasive procedures in the developed world, open prostatectomy is still quite popular in Africa. Further research should focus not only on the reason for these disparities in management but also on the rationale for the selection of medical, surgical, or phytotherapy in African urological centres.

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“…Herbal extracts endowed with antioxidant/anti-inflammatory effects have been long considered as a reliable strategy to blunt the burden of oxidative stress and inflammation in prostate and ovary tissue [ 3 , 4 , 5 ]. Pollen extract represents an innovative approach for the management of the clinical symptoms related to prostatitis [ 6 ], being also able to relieve inflammation and hyperplasia of the prostate [ 7 ], with anticancer potential most likely associated with antioxidant and antimutagenic effects [ 8 ]. In this case, pollen appears to relieve pain in patients with benign prostatic hyperplasia, at least in the early stages.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of PollenAid Plus Soft Gel Capsules’ Hydroalcoholic Extract in Isolated Prostates and Ovaries Exposed to Lipopolysaccharide

et al. 2022

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Pollen extract represents an innovative approach for the management of the clinical symptoms related to prostatitis and pelvic inflammatory disease (PID). In this context, the aims of the present work were to analyze the phenolic composition of a hydroalcoholic extract of PollenAid Plus soft gel capsules, and to evaluate the extract’s cytotoxic effects, in human prostate cancer PC3 cells and human ovary cancer OVCAR-3 cells. Additionally, protective effects were investigated in isolated prostate and ovary specimens exposed to lipopolysaccharide (LPS). The phytochemical investigation identified catechin, chlorogenic acid, gentisic acid, and 3-hydroxytyrosol as the prominent phenolics. The extract did not exert a relevant cytotoxic effect on PC3 and OVCAR-3 cells. However, the extract showed a dose-dependent inhibition of pro-inflammatory IL-6 and TNF-α gene expression in prostate and ovary specimens, and the extract was effective in preventing the LPS-induced upregulation of CAT and SOD gene expression, which are deeply involved in tissue antioxidant defense systems. Finally, a docking approach suggested the capability of catechin and chlorogenic acid to interact with the TRPV1 receptor, playing a master role in prostate inflammation. Overall, the present findings demonstrated anti-inflammatory and antioxidant effects of this formulation; thus, suggesting its capability in the management of the clinical symptoms related to prostatitis and PID.

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Treatment of Benign Prostatic Hyperplasia by Natural Drugs

Cited by 66 publications

References 206 publications

Nephroprotective Plants: A Review on the Use in Pre-Renal and Post-Renal Diseases

Nephroprotective Plants: A Review on the Use in Pre-Renal and Post-Renal Diseases

A Scoping Review of the Management of Benign Prostate Hyperplasia in Africa

Protective Effects of PollenAid Plus Soft Gel Capsules’ Hydroalcoholic Extract in Isolated Prostates and Ovaries Exposed to Lipopolysaccharide

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