Treatment of bone, joint, and soft-tissue infections with oral ciprofloxacin

Greenberg, Richard N.; Kennedy, Denis; Reilly, Patrick; Luppen, Kevin L.; Weinandt, William J.; Bollinger, M; Aguirre, F; Kodesch, F.; Saeed, Ahmed

doi:10.1128/aac.31.2.151

Cited by 88 publications

(66 citation statements)

References 18 publications

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“…Although this result was formally statistically insignificant, we detected this tendency in all analyses performed. Our failure risk of 24% is congruent with the 20% [12], 21% [13], 25% [27], 27% [14] or 30% [9] failure rates reported for pseudomonal osteoarticular infections, although lower (5% [11]; 7% [21]) or higher failure rates ranging from 33% [23], 35% [24], 38% [22] to 39% [15] also exist in small case series from the 1980s. Development of resistance among failure cases to the antimicrobial agents used during therapy occurred in 15%, which is congruent with the 13-24% risk after a prolonged antibiotic monotherapy during three-four months [9,24].…”

Section: Discussionsupporting

confidence: 65%

“…P. aeruginosa accounts for an absolute minority of all osteoarticular pathogens [1], and most reports are either case series involving around 20-30 cases [9][10][11][12][13] or even less [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Moreover, these reports subsume P. aeruginosa under other Gram-negative pathogens [9,12,13,19], including anaerobes [10,28], and lack adjustment for case mix [9,10,19,21].…”

Section: Introductionmentioning

confidence: 99%

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Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study

Seghrouchni

Delden

Dominguez

et al. 2011

International Orthopaedics (SICOT)

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Purpose Osteoarticular infections due to methicillinsusceptible Staphylococcus aureus (MSSA) or its methicillin-resistant variant (MRSA) are feared due to treatment failures. According to clinical experience, Pseudomonas aeruginosa may reveal less long-term remission than S. aureus. Methods A case-controlled study comparing outcomes of osteoarticular infections due to P. aeruginosa vs S. aureus was performed at Geneva University Hospitals. Results A total of 111 S. aureus (including 37 MRSA) and 20 P. aeruginosa osteoarticular infections were analysed in 131 patients: arthroplasties (n=38), fracture fixation devices (n=56), native joint arthritis (n=7) and osteomyelitis without implant (n=30). The median active follow-up time was 4 years. The patients underwent a median number of two surgical interventions for P. aeruginosa infections compared to two for S. aureus (two for MRSA), while the median duration of antibiotic treatment was 87 days for P. aeruginosa and 46 days for S. aureus infections (58 days for MRSA) (all p>0.05). Overall, Pseudomonas-infected patients tended towards a lower remission rate than those infected with S. aureus (12/20 vs 88/111; p=0.06). This was similar when P. aeruginosa was compared with MRSA alone (12/20 vs 30/37; p=0.08). In multivariate logistic regression analyses adjusting for case mix, odds ratios (OR) for remission were as follows: P. aeruginosa vs S. aureus [OR 0.4, 95% confidence interval (CI) 0.1-1.2], number of surgical interventions (OR 0.6, 95% CI 0.5-1.0) and duration of antibiotic treatment (OR 1.0, 95% CI 1.0-1.0). Conclusions Despite a similar number of surgical interventions and longer antibiotic treatment, osteoarticular infections due to P. aeruginosa tended towards a lower remission rate than infections due to S. aureus in general or MRSA in particular.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study

Seghrouchni

Delden

Dominguez

et al. 2011

International Orthopaedics (SICOT)

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“…Greenberg et al [23] reported that none of six patients with osteomyelitis caused by Staphylococcus aureus (monoculture) was cured with ciprofloxacin therapy.…”

Section: Antibiotic Discussionmentioning

confidence: 99%

Correlation between In Vivo and In Vitro Efficacy of Antimicrobial Agents against Foreign Body Infections

Widmer

Frei

Rajacic

et al. 1990

Journal of Infectious Diseases

298

186

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“…39 S salivarius bacteremia has also been reported during ciprofloxacin therapy for osteomyelitis. 40 Therefore, treatment as well as prophylaxis with ciprofloxacin may not prevent future episodes of S salivarius SBP. On the other hand, gatifloxacin has been reported to be highly active in vitro against VGS isolates.…”

Section: Discussionmentioning

confidence: 99%

Streptococcus salivarius bacteremia and spontaneous bacterial peritonitis in liver transplantation candidates

et al. 2007

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Bacterial infections are a serious complication of end-stage liver disease (ESLD) that occurs in 20% to 60% of patients. We retrospectively reviewed medical records of patients with ESLD who were identified by our microbiology laboratory as having Streptococcus salivarius bacteremia. Of 592 patients listed for transplantation between January 1998 and January 2006, 9 (1.5%) had 10 episodes of S salivarius bacteremia. Of 2 patients already receiving quinolone prophylaxis for spontaneous bacterial peritonitis (SBP), 1 later presented with a second episode. The male-to-female ratio was 1:1.2. Medians for age, Model for End-Stage Liver Disease score, and Child-Turcotte-Pugh score were 50 years, 17, and 10, respectively. Presenting symptoms and signs in 10 episodes of infection were ascites (in 8 episodes), elevated temperature (6), abdominal pain (5) Bacterial infections are a common and serious complication of end-stage liver disease (ESLD). Their prevalence has been reported to range from 20 to 60%. 1,2 They are associated with increased morbidity and overall in-hospital mortality.1,2 Proposed mechanisms for increased risk of infection are changes in humoral immunity with a decreased synthesis in the complement system, 3 a decrease in the phagocytosis capability of the hepatic reticuloendothelial system, 4 an alteration in the function of neutrophils, 5,6 and a reduction in opsonic activity of ascitic fluid. 7 In addition, rupture of natural barriers induced by invasive diagnostic or therapeutic procedures may be involved in the pathogenesis of infections.Commonly observed infections in cirrhotic patients are pneumonia, urinary tract infection, spontaneous bacterial peritonitis (SBP), and bacteremia. Most of these infections are community acquired. In 1 series, two-thirds of the episodes were caused by gram-negative bacteria, 21% by gram-positive bacteria, and 3% by anaerobic bacteria. 8 In a more recent series of 117 cases of bacteremia, about one-half of the infections were caused by gram-negative bacteria and about onehalf by gram-positive bacteria. 9 We have encountered cases of S salivarius bacteremia among patients listed for liver transplantation at our tertiary care academic medical institution. Herein, we present our experience with this infection in patients with ESLD who were managed at our institution. PATIENTS AND METHODSAfter we encountered 2 liver transplantation candidates with S salivarius bacteremia, we reviewed the electronic Abbreviations: ESLD, end-stage liver disease; SBP, spontaneous bacterial peritonitis; VGS, viridans group streptococci.

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Treatment of bone, joint, and soft-tissue infections with oral ciprofloxacin

Cited by 88 publications

References 18 publications

Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study

Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study

Correlation between In Vivo and In Vitro Efficacy of Antimicrobial Agents against Foreign Body Infections

Streptococcus salivarius bacteremia and spontaneous bacterial peritonitis in liver transplantation candidates

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