Treatment of Brain Metastases

Lukas, Rimas V.; Gabikian, Patrik; Garza, Madeline; Chmura, Steven J.

doi:10.1159/000362389

Cited by 20 publications

(13 citation statements)

References 46 publications

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“…Most studies (reviewed in [26, 62, 72, 78, 80, 81]) have clearly demonstrated that the addition of WBRT to surgery or SRS was associated with improved local control rates and decreased neurologic deaths but did not improve outcome in terms of survival (class I evidence). With respect to BMHCC, a retrospective study by Choi et al [33] concluded that resection in conjunction with WBRT showed considerably prolonged survival (33.6 weeks).…”

Section: Radiotherapymentioning

confidence: 99%

“…SRS has become an increasingly popular treatment option for patients with 1-4 metastases [81], and can be considered as an alternative for surgery or a salvage treatment in patients who are not candidates for surgery [74, 82–84]. Typically, when the metastases are larger than 3-4 cm or immediate mass relief is required, surgery is preferred [63, 74].…”

Section: Radiotherapymentioning

confidence: 99%

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Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Wang

Lin

et al. 2017

Oncotarget

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The incidence of brain metastases from hepatocellular carcinoma (BMHCC) is becoming more frequent than that of the past as a result of prolonged survival of patients with HCC. Compared with brain metastases from other types of cancer, BMHCC tends to exhibit a high incidence of intracerebral hemorrhage (ICH) and poor liver function. Unfortunately, the prognosis is extremely poor for patients with BMHCC owing to the limited treatment selection. Currently, optimal treatment requires multidisciplinary approaches including surgery, whole-brain radiation therapy and stereotactic radiosurgery. Besides these traditional approaches, novel treatments such as target therapy and immunotherapy provide an opportunity to improve the survival of these patients. This review provides an overview of the incidence, characteristics, prognosis, and current and potential future management strategies for BMHCC.

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Section: Radiotherapymentioning

confidence: 99%

Section: Radiotherapymentioning

confidence: 99%

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Wang

Lin

et al. 2017

Oncotarget

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“…Important advances in our understanding of brain metastases are underway [ 1 , 2 ]. While there have been many recent reviews of brain metastases [ 3 – 6 ] as well as more focused reviews on non-small cell lung cancer (NSCLC) brain metastases [ 7 – 9 ] there has been a paucity of contemporary reviews focusing on small cell lung cancer (SCLC) brain metastases. A broad overview of SCLC can be found in a recent review [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

State-of-the-art considerations in small cell lung cancer brain metastases

et al. 2017

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BackgroundSmall cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments.DesignA comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed.ResultsSCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed.ConclusionsA clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients.

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“…In this update, we first discuss ongoing and future developments in the neurosurgical management of both metastatic and primary CNS tumors, before shifting to the medical management of high-grade gliomas (HGG). The overall management of CNS metastases 1 and gliomas 2 has been reviewed recently, and so here we focus on how neurosurgical interventions will feature within the wider context of the ongoing advances in neuro-oncology. 3…”

Section: Goals Of Neurosurgical Interventionmentioning

confidence: 99%

A Survey of the Neuro-Oncology Landscape

Lukas

Dey

et al. 2018

J Clin Neurol

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The field of neuro-oncology is evolving rapidly. Many important advances have recently been reported, and other promising investigations have the potential to soon make substantial impacts in the field, especially in the areas of high-grade gliomas and brain metastases. We present an overview of the current status of this field, highlighting the key recent advances as well as representative work of key clinical investigations, since these concepts have the potential to influence clinical management if they are demonstrated to be safe and efficacious. This overview includes some work that has only appeared in abstract form in order to provide a timely understanding of how the field is actively changing and what may lie on the horizon. We focus on both medical and surgical neuro-oncology advances in this highly multidisciplinary subspecialty.

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Treatment of Brain Metastases

Cited by 20 publications

References 46 publications

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

State-of-the-art considerations in small cell lung cancer brain metastases

A Survey of the Neuro-Oncology Landscape

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