Treatment of breast carcinoma in patients with clinically negative axillary lymph nodes using radiotherapy versus axillary dissection

Abstract

A series of new polyimides was prepared by reacting 2,6‐diaminopyridine with various aromatic dianhydrides in DMF in 1 : 1 mole ratio. All the resulting polyimides were readily soluble in organic solvents such as dimethylformamide, N,N‐dimethylacetamide, pyridine, m‐cresol, THF, etc. They also show good film‐forming ability. The polyimides exhibit good thermal stability and mechanical properties. The polymers have high Tg in the range of 252–296°C. The inherent viscosities of the polymers vary from 0.81 to 1.28 dL/g. A new class of bismaleimide and polyaspartimide as also synthesized. All the resulting polymer structures were characterized by FTIR and elemental analysis. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 1846–1853, 2004

Radiation therapy after breast-conserving surgery

“…We have previously reported a retrospective analysis of the results of treatment with AxD versus AxR in these patients. 106 The results revealed that the 10-year overall survival rates for patients with T1 tumors were 94.7% in the AxD group and 92.7% in the AxR group; the corresponding rates for those with T2 tumors were 92.5% in the AxD group and 89.1% in the AxR group. For those with T1-2N0 tumors, the survival rate was similar in the AxD and AxR groups (Fig.…”

Outcomes of Clinically Node-Negative Breast Cancer Without Axillary Dissection: Can Preserved Axilla Be Safely Treated With Radiation After a Positive Sentinel Node Biopsy?

“…Since 1988, we began to substitute ALNI for ALND in patients with cN0 disease. 3 From 2001, we introduced SLNB without changing our policy to preserve the axilla. Patients with a negative SLNB usually received ALNI by extended tangential fields, and those with a positive SLNB mainly received RNI by an additional third field to the supraclavicular fossa.…”

“…In 2004, we reported that patients with cN0 were safely treated with axillary lymph node irradiation (ALNI). 3 With a longer follow-up time, we analyzed whether ALNI could control cN0 disease, including those with a positive SLNB. We also calculated additional risks of having more positive nodes after a positive SLNB to estimate the possible benefit of RNI.…”

Axillary Irradiation with High Tangent Fields for Clinically Node-Negative Breast Cancer: Can 3-D Conformal Radiotherapy with a Field-in-Field Technique Better Control the Axilla?

“…1). Since 1988, we have been substituting axillary lymph node irradiation for ALND in patients with cN0 disease [5]. In 1999, we began to increase the use of high tangential irradiation for these patients, followed by the introduction of SLNB, without changing our policy to preserve the axilla [6].…”

“…However, few data exist on the correlation between technical observations and clinical outcomes. We have reported that patients with cN0 disease were safely treated with axillary lymph node irradiation without ALND [5,6]. In 2004, we began to implement computed tomography (CT)-based 3-dimensional (3-D) treatment planning using a field-in-field technique to improve the dose distribution of both the breast and the axilla [7].…”