Treatment of bullous pemphigoid in Chinese patients with<i>Tripterygium wilfordii</i>Hook F

Ge, Xiao-Lei; Li, Sizhe; Jin, Xin-Xing; Jin, Hongzhong; Zuo, Ya‐Gang

doi:10.1111/dth.13721

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…Some reports have also found a temporal association between the use of herbal supplement intake and the onset of skin disease or flare-up of skin diseases [35,36]. On the other hand, the intake of low-dose Tripterygium wilfordii Hook F, a traditional Chinese herb, was shown to have anti-inflammatory effects in a small case series of patients with mild and moderate BP [37]. Therefore, the disclosure of CAM use by patients to their healthcare providers is important, especially in the case of phytotherapy.…”

Section: Discussionmentioning

confidence: 99%

Use of Complementary and Alternative Medicine in Patients with Autoimmune Bullous Dermatoses: A Cohort Study Analysis of a Rare Disease Group

Hübner¹,

Sarhan²,

Schauer³

2023

Complement Med Res

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Introduction: Autoimmune bullous diseases (AIBD) are a heterogeneous group of rare autoantibody mediated blistering dermatoses of the skin and/ or mucous membranes. Their incidence is around 20 new cases per million inhabitants per year in Germany. Patients with chronic, oncological or rare diseases often urge for a holistic therapeutic approach that includes complementary and alternative medicine (CAM). So far, only few contradictory reports on CAM in pemphigoid or pemphigus disease exist. The purpose of this study was to determine the frequency, motives, and satisfaction with the use of alternative treatments in patients with AIBD and to provide a basis for further investigation. Methods: We used a structured online questionnaire, consisting of 20 questions to survey patients with AIBD and their relatives. The German pemphigus and pemphigoid self-help groups were responsible for distributing anonymised questionnaires. In total, we recovered 97 questionnaires, 63 of which met full inclusion criteria (24 males and 39 females). Results: Of the included participants, more than half had a currently active disease. Of all patients, 58.7% stated that they had used CAM at least once. Women were more likely to use CAM, whereas age and education showed no association showed no association to CAM use. The main motives for using CAM were “doing something for oneself” and “opportunity to contribute to treatment” (38.1% each). The internet (23.8%) was the most common source of information, and vitamins were the most frequently used therapy (49.2%). Conclusion: Our results provide new insights into the demand for CAM within this rare disease patient group. Physicians should be aware of these methods to meet patient needs, but also be able to identify potential barriers such as risks and interactions.

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Section: Discussionmentioning

confidence: 99%

Use of Complementary and Alternative Medicine in Patients with Autoimmune Bullous Dermatoses: A Cohort Study Analysis of a Rare Disease Group

Hübner¹,

Sarhan²,

Schauer³

2023

Complement Med Res

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“…In addition to Western medicine treatment, traditional Chinese medicine treatment is currently receiving increasing attention, and its efficacy is considerable. For example, Ge et al (27) discovered that Tripterygium wilfordii Hook F was safe and effective in treating mild to moderate BP, with much fewer adverse effects than hormone treatment. In this case, we chose berberine primarily based on traditional Chinese medicine's basic theory and syndrome differentiation for patients.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Bullous Pemphigoid Lesions by Berberine Stamp Therapy: A Case Report and Literature Review

Cheng

Wang

et al. 2022

Front. Med.

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Bullous pemphigoid (BP) is a life-threatening autoimmune disease of the skin that is mainly characterized by a large range of tension blisters and intense itching of the skin. The 1-year mortality rate of BP was 23.5%. Superinfection caused by skin lesion ulceration is one of the important causes of disease death. Therefore, it is challenging to control infection and improve skin wound healing. Here, we report the case of an elderly woman who presented with BP and involved the oral mucosa. The patient was successfully treated with hormones combined with topical berberine, and 95% of the patients’ lesions healed completely after 1 month. In addition, we inductively analyzed the current treatments for BP to provide a reference for BP clinical treatment.

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“…6 In China, Tripterygium wilfordii Hook F (TwHF) is widely used for treating autoimmune and inflammatory diseases such as BP due to its significant anti-inflammatory and immunosuppressive properties. 9,10 To achieve complete remission, BP patients usually need several years of treatment and adverse effects during treatment may lead to related complications or even death. 11 Recently, multiple studies have suggested that the structure and composition of the gut microbiota (GM) in various immune diseases patients exhibit significant alterations.…”

Section: Introductionmentioning

confidence: 99%

Identification of gut microbiota dysbiosis in bullous pemphigoid under different disease activity

Hu,

Wu,

Fan

et al. 2023

Experimental Dermatology

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Bullous pemphigoid (BP) is a severe autoimmune blistering disease affecting patients' quality of life. Gut microbiota (GM) dysbiosis have been investigated to be associated with multiple autoimmune diseases. However, the relationship between GM and BP onset and remission remains to be established by a systematic study. We conducted a study that enrolled 24 patients with BP onset (BP group), 24 patients under remission stage (BP‐R group) and 24 healthy controls (HC group). We applied 16S rRNA sequencing on faecal samples and revealed a separation of the microbiota structure. At the family level, Lachnospiraceae, Prevotellaceae and Veillonellaceae were more abundant in the HC and BP‐R groups, while Bacteroidaceae, Ruminococcaceae and Enterobacteriaceae were more abundant in the BP group. Bugbase analysis revealed the potentially pathogenic bacteria had an increasing trend in the BP group compared with the HC group and this variation vanished in the BP‐R group. At the amplicon sequence variants (ASV) level, Bacteroides ovatus (ASV40) and Veillonella dispar (ASV140) significantly decreased, while Prevotella copri (ASV54) increased in the BP group compared to the HC and BP‐R groups. The HC group and BP‐R group shared similar abundance. Furthermore, by correlation analysis, we investigated key ASVs correlated with clinical parameters and found some discriminate biomarkers between the BP and BP‐R groups. Our study established a dynamic GM profile in BP patients under different disease activity, providing a new direction to understand the role of GM in BP pathogenesis and therapeutic effects.

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Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F

Cited by 6 publications

References 20 publications

Use of Complementary and Alternative Medicine in Patients with Autoimmune Bullous Dermatoses: A Cohort Study Analysis of a Rare Disease Group

Use of Complementary and Alternative Medicine in Patients with Autoimmune Bullous Dermatoses: A Cohort Study Analysis of a Rare Disease Group

Successful Treatment of Bullous Pemphigoid Lesions by Berberine Stamp Therapy: A Case Report and Literature Review

Identification of gut microbiota dysbiosis in bullous pemphigoid under different disease activity

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