Treatment of camptocormia with botulinum toxin

Bertram, Kelly; Stirpe, Paola; Colosimo, Carlo

doi:10.1016/j.toxicon.2015.06.004

Cited by 22 publications

(10 citation statements)

References 63 publications

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“…It is beyond the scope of this review to describe the various studies, most of which are relatively small and open-label trials. BoNT has been reported to be safe and effective in the treatment of oromandibular dystonia, including bruxism [33][34][35][36] and jaw-opening dystonia 37 ; tremors, including essential tremor, parkinsonian rest tremors, dystonic tremors, task-specific tremors, and cerebellar tremors [38][39][40][41][42] ; tics 38 ; and various aspects of parkinsonism 43 besides tremor, including sialorrhea, 44,45 anterocollis/camptocormia, 46 overactive bladder, 47,48 pain, 49 depression, 50 and many other movement disorders or related conditions. 51 Spasticity is another form of movement disorder in which BoNT has been increasingly used.…”

Section: Clinical Use Of Bontmentioning

confidence: 99%

Botulinum toxin: State of the art

2017

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Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic agents in modern medicine with more clinical applications than any other drug currently on the market. Initially developed in the treatment of strabismus and neurologic movement disorders, the use of botulinun neurotoxin has been expanding during the past 3 decades to include the treatment of a variety of ophthalmologic, gastrointestinal, urologic, orthopedic, dermatologic, dental, secretory, painful, cosmetic, and other conditions. In addition to onabotulinumtoxinA (Botox), abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin), and RimabotulinumtoxinB (Myobloc or NeuroBloc) there are other novel botulinun neurotoxin products currently in development. With a better understanding of the cellular mechanisms of botulinun neurotoxin and advances in biotechnology, future botulinun neurotoxin products will likely be even more effective and customized to the specific indication and tailored to the needs of the patients. © 2017 International Parkinson and Movement Disorder Society.

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Section: Clinical Use Of Bontmentioning

confidence: 99%

Botulinum toxin: State of the art

2017

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“…47 Algunos pacientes con distonía de la musculatura abdominal podrían beneficiarse parcialmente de la inyección de toxina botulínica en los músculos rectos abdominales, oblicuo externo y psoas ilíaco. 7,48,49 Se ha demostrado que la neuroestimulación bilateral del núcleo subtalámico mejora los principales síntomas del Parkinson. 46,50 Sin embargo, la neuroestimulación ha demostrado ser eficaz en el SEI secundario al Parkinson, si se efectúa dentro de los primeros 1.5 años del inicio de los síntomas de la inclinación del tronco.…”

Section: Tratamiento Del Sei En Pacientes Con Enfermedad De Parkinsonunclassified

“…51 Los pacientes con una distonía aislada de la musculatura abdominal podrían beneficiarse con las inyecciones de toxina botulínica en los rectos abdominales y en el oblicuo externo. 49 Como última alternativa, la estimulación cerebral profunda del globo pálido interno resultó eficaz en este subgrupo de pacientes con SEI por una distonía primaria. 52 tratamiento del SEI en pacientes con miopatías inflamatorias y miopatías primarias En el caso de las miopatías inflamatorias o las polineuropatías desmielinizantes, la elección de tratamiento inmunosupresor dependerá del cuadro específico y de su estadio.…”

Section: Tratamiento Del Sei De Origen Distónicounclassified

Síndrome de la espalda inclinada. Presentación de cuatro casos y revisión de la bibliografía. [Bent spine syndrome. Presentation of four cases and literature review]

Covaro

Vilà-Canet²,

Ciccolo

et al. 2019

Rev. Asoc. Arg. Ort. y Traumatol

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El síndrome de la espalda inclinada o camptocormia es una causa de desequilibrio sagital del tronco no estructurada de difícil manejo médico y quirúrgico. Puede ser secundario a enfermedades del sistema nervioso central o periférico, o de origen primario muscular, como la atrofia aislada de la musculatura paravertebral espinal. El diagnóstico se basa en la evaluación clínica, los estudios por imágenes, el electromiograma y la biopsia muscular. El síndrome de la espalda inclinada, cualquiera fuera su causa, tiene un pronóstico pobre, los síntomas suelen progresar hasta afectar la bipedestación de manera irreversible. Presentamos un análisis retrospectivo de cuatro casos de síndrome de la espalda inclinada tratados en nuestro centro y una revisión de la bibliografía. AbstractIntroduction: The bent spine syndrome (BSS) or camptocornia is a cause of unstructured sagittal imbalance of difficult medical and surgical management.Objective: To describe the causes of BSS and how to approach its treatment.Materials and Methods: Retrospective analysis of 4 cases of BSS treated at our center and review of the literature.Results: The 4 cases were women between 60 and 82 years of age, 3 due to an isolated atrophy of the paravertebral spinal erectorae musculature and 1 case due to an inflammatory myopathy.Conclusions: The prognosis of any BSS is poor, so the symptoms usually progress to irreversible difficulty to maintain upright posture.

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“…BTX was injected into the rectus abdominis, abdominal external oblique and ilio-psoas muscles either singly or as a combination of several. Different types of botulinum toxin A were used with different dosages per muscle [134]. Of a total of 23 PD patients with camptocormia treated with BTX, four (17%) improved to some extent while 19 showed no effect.…”

Section: Treatment Options For Camptocormiamentioning

confidence: 99%

Pathophysiological Concepts and Treatment of Camptocormia

Margraf

Wrede

Deuschl

et al. 2016

Journal of Parkinson’s Disease

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Camptocormia is a disabling pathological, non-fixed, forward bending of the trunk. The clinical definition using only the bending angle is insufficient; it should include the subjectively perceived inability to stand upright, occurrence of back pain, typical individual complaints, and need for walking aids and compensatory signs (e.g. back-swept wing sign). Due to the heterogeneous etiologies of camptocormia a broad diagnostic approach is necessary. Camptocormia is most frequently encountered in movement disorders (PD and dystonia) and muscles diseases (myositis and myopathy, mainly facio-scapulo-humeral muscular dystrophy (FSHD)). The main diagnostic aim is to discover the etiology by looking for signs of the underlying disease in the neurological examination, EMG, muscle MRI and possibly biopsy. PD and probably myositic camptocormia can be divided into an acute and a chronic stage according to the duration of camptocormia and the findings in the short time inversion recovery (STIR) and T1 sequences of paravertebral muscle MRI. There is no established treatment of camptocormia resulting from any etiology. Case series suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) is effective in the acute but not the chronic stage of PD camptocormia. In chronic stages with degenerated muscles, treatment options are limited to orthoses, walking aids, physiotherapy and pain therapy. In acute myositic camptocormia an escalation strategy with different immunosuppressive drugs is recommended. In dystonic camptocormia, as in dystonia in general, case reports have shown botulinum toxin and DBS of the globus pallidus internus (GPi-DBS) to be effective. Camptocormia in connection with primary myopathies should be treated according to the underlying illness.

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Treatment of camptocormia with botulinum toxin

Cited by 22 publications

References 63 publications

Botulinum toxin: State of the art

Botulinum toxin: State of the art

Síndrome de la espalda inclinada. Presentación de cuatro casos y revisión de la bibliografía. [Bent spine syndrome. Presentation of four cases and literature review]

Pathophysiological Concepts and Treatment of Camptocormia

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