Treatment of Canine Hemangiosarcoma: 2000 and Beyond

Clifford, Craig; Mackin, Andrew; Henry, Carolyn J.

doi:10.1111/j.1939-1676.2000.tb02262.x

Cited by 135 publications

(124 citation statements)

References 54 publications

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“…Despite surgery and intensive chemotherapy, the median survival time for dogs diagnosed with HSA is little more than 6 months. [5][6][7][8] This naturally occurring disease of dogs resembles human angiosarcoma. Angiosarcomas are uncommon soft tissue sarcomas that can arise in a variety of locations, including liver, spleen, skin, breast, and endocrine organs.…”

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confidence: 99%

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium

Fosmire

Dickerson

Scott

et al. 2004

Laboratory Investigation

123

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Hemangiosarcoma (HSA) is a common untreatable cancer of dogs that resembles human angiosarcoma. Detailed studies of these diseases have been historically hindered by the paucity of suitable reagents. Here, we show that expression of CD117 (c-Kit) can distinguish primitive (malignant) from mature (benign) proliferative endothelial lesions, and we describe eight independent cell lines derived from canine HSA explants. Endothelial origin was confirmed by sustained expression of surface CD105 (endoglin), CD146 (MUC18), and CD51/CD61 (a v b 3 integrin). The cell lines showed anchorage-independent growth and were motile and invasive when cultured on a basement membrane matrix. They required endothelial growth factors for growth and survival, and they could be induced to form tubular structures resembling blood vessels when cultured under low calcium conditions. The formation of vessel-like structures was blocked by nicotine, and restored by FK506, suggesting that 'nuclear factor of activated T cells' activity prevents differentiation of these cells. In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular.

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confidence: 99%

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium

Fosmire

Dickerson

Scott

et al. 2004

Laboratory Investigation

123

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“…It is a malignant, aggressive tumour that arises from the mutated vascular endothelial cells (Murakami et al, 2001). Hemangiosarcoma represents up to 7% of all tumours and 12% to 21% of all mesenchymal neoplasms in dogs (Clifford et al, 2000;Smith, 2003;Schultheiss, 2004;Thamm, 2007). Two forms of the hemangiosarcomas i.e., visceral and dermal forms exists.…”

Section: Introductionmentioning

confidence: 99%

Histopathological features of cutaneous tumours arising from the vascular endothelial cells in dogs

Jayasree¹,

Nasreen²,

Sh³

et al. 2016

JEBAS

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Cutaneous growths arising from the endothelial cells of blood vessels were studied in three dogs (Two in male cocker spaniels and one in male Labrador). All the three growths were surgically excised and referred to the Department of Veterinary Pathology, Tirupati for histopathological confirmation during the period from August 2015 to December 2015.Gross examination revealed, firm reddish, soft dark red and soft greyish red coloured masses and are diagnosed based on histopathological features as hemangiosarcoma, cavernous hemangioma and lipohemangioma respectively. In the case of hemangiosarcoma, severe necrosis along with the presence of blastomyces organisms as a secondary infection was also noticed. Occurring of these tumours might be because of exposure of lightly pigmented areas to Ultra Violet radiation.

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“…3,5,[8][9][10] Hemangiosarcoma (HSA) is an aggressive malignancy primarily affecting older male, large-breed dogs. [11][12][13][14][15][16][17] HSA typically affects the spleen, right atrium, and skin or sub- cutis. [12][13][14][15][16][17] At the time of diagnosis, distant metastatic disease is often present, and to date, multimodality therapy has had a limited effect in the treatment of visceral disease.…”

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confidence: 99%

“…[11][12][13][14][15][16][17] HSA typically affects the spleen, right atrium, and skin or sub- cutis. [12][13][14][15][16][17] At the time of diagnosis, distant metastatic disease is often present, and to date, multimodality therapy has had a limited effect in the treatment of visceral disease. 12,14 Immunomodulating agents, nontraditional drug delivery systems, and other anti-angiogenic agents are currently being studied for their potential roles in the treatment of canine HSA.…”

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confidence: 99%

“…12,14 Immunomodulating agents, nontraditional drug delivery systems, and other anti-angiogenic agents are currently being studied for their potential roles in the treatment of canine HSA. 17 Lymphoma (LSA) is one of the most common canine malignancies, with an incidence of between 13 and 24 per 100,000 dogs at risk. 18,19 LSA affects primarily middle-aged to older dogs, and most studies do not demonstrate a definitive gender bias.…”

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confidence: 99%

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Endostatin Concentrations in Healthy Dogs and Dogs with Selected Neoplasms

Rossmeisl

Bright

Tamarkin

et al. 2002

Veterinary Internal Medicne

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Endostatin prevents angiogenesis and tumor growth by inhibiting endothelial cell proliferation and migration. The purpose of this study was to determine serum endostatin concentrations in 53 healthy dogs and in 38 dogs with confirmed malignant neoplasms. Endostatin concentration was determined with a competitive enzymatic immunoassay (EIA) with rabbit polyclonal antibody generated against a recombinant canine endostatin protein. Both the presence of cancer and increasing age were associated with increased serum concentration of endostatin. Endostatin concentration in healthy dogs was 87.7 Ϯ 3.5 ng/mL. Upper and lower limits of the reference range for serum endostatin concentration in healthy dogs were 60 and 113 ng/mL. Dogs with lymphoma (LSA) and hemangiosarcoma (HSA) had endostatin concentrations of 107 Ϯ 9.3 ng/mL. In conclusion, this study demonstrates that endostatin can be quantified in dogs and that endostatin concentrations are high in dogs with HSA and LSA.Key words: Angiogenesis; Neoplasia; Vascular biology.A ngiogenesis plays an integral role in a variety of normal physiologic states and has been recognized for its role in the pathogenesis of diseases such as atherosclerosis and neoplasia. 1,2 Biologic tumor behavior is linked to the ability of neoplasms to induce endothelial cell growth and organization, with tumor growth being dependent on regulation of angiogenesis. [3][4][5][6] With in vivo and in vitro models, researchers have shown that without recruitment of a new blood supply, tumor size is limited to a few cubic millimeters because of a lack of energy substrate delivery, and expression of the metastatic phenotype is delayed or absent. 3,5 Alternatively, aggressive malignancies with high distant metastatic potential suppress anti-angiogenic factors, stimulate local production of angiogenic substances by normal host tissues, and endogenously produce active angiogenic compounds. 2,4,7 Endostatin, a carboxy-terminal fragment of collagen XVIII originally isolated from a murine hemangioendothelioma cell line, inhibits angiogenesis by preventing endothelial proliferation and migration. 3,5 Anti-neoplastic properties of endostatin have been demonstrated in vitro and in several animal models with multiple neoplastic cell lineages, and increased circulating endostatin concentrations may be associated with the development or recurrence of neoplasia in mice and humans. 3,5,[8][9][10] Hemangiosarcoma (HSA) is an aggressive malignancy primarily affecting older male, large-breed dogs. 11-17 HSA typically affects the spleen, right atrium, and skin or sub-

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Treatment of Canine Hemangiosarcoma: 2000 and Beyond

Cited by 135 publications

References 54 publications

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium

Histopathological features of cutaneous tumours arising from the vascular endothelial cells in dogs

Endostatin Concentrations in Healthy Dogs and Dogs with Selected Neoplasms

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