Treatment of canine transmissible venereal tumor using L-asparaginase, prednisone, and surgery in a clinical chemotherapy-resistant case

Silva, Daniella Matos da; Reusing, Mhayara Samile de Oliveira; Franciosi, A; Belo, Carlos Eduardo Penner; Gonçalves, Kamila Alcalá; Sousa, Renato Silva de; Guérios, S. D.

doi:10.3906/vet-1309-23

Cited by 6 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These techniques require expertise since it can cause postoperative urinary diseases. Da Silva et al (2014) used a combination of L-asparagine, prednisone, and surgery in a clinical case, wherein the dog remained tumor-free for 12 months. The authors suggest that it is possible that the use of any of the treatments alone can cause the response seen in this case.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lomustine therapy for vincristine-resistant canine transmissible venereal tumor: a case report

et al. 2021

View full text Add to dashboard Cite

Canine transmissible venereal tumor (CTVT) is a transmissible cancer that affects the external genitalia of dogs. In this study, a female canine with CTVT in the vagina was treated with vincristine (0.75 mg/m 2 ; intravenous (IV); weekly for eight cycles), the currently preferred drug for CTVT, but without any progress. Therefore, this case was considered resistant to vincristine, and the preferred alternative chemotherapy, doxorubicin, was suggested. However, based on echocardiographic evidence, the patient could not be administered doxorubicin. Thus, the administration of lomustine was proposed. Although there are no studies to support this decision, the authors based their decision on the fact that lomustine is effective for round cell tumors, and that CTVT belongs to this tumor group. After three doses (60 mg/m 2 ; every 3 weeks) complete remission was achieved. The use of lomustine at a dose of 60 mg/m 2 every 3 weeks for vincristine-resistant CTVT proved to be effective, without any harmful side effects. The treatment is cost-effective and simple to manage.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Vincristine is used to treat lymphomas, sarcomas, and immunemediated thrombocytopenia (Das & Das, 2000;Nak et al, 2005;Ogilvie & Moore, 2008). Other treatments have been developed with varying success rates (Da Silva et al, 2014;Kunakornsawat et al, 2010;Rogers et al, 1998;Spugnini et al, 2008;Sudjaidee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Lomustine therapy for vincristine-resistant canine transmissible venereal tumor: a case report

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Es un tumor que suele aparecer en genitales, mucosa oral o nasal, y se transmite de forma horizontal, normalmente durante el coito, por la implantación de células tumorales en mucosas (Da Silva, 2014).…”

Section: Tumor Venéreo Transmisible (Tvt)unclassified

Estrategias terapéuticas contra el cáncer en animales de compañía

Ruiz-Castillo¹,

Arroyo-León²,

Cervantes-Arias³

2021

teq

View full text Add to dashboard Cite

Cancer is one of the main causes of death in dogs and cats. What was once considered a death sentence is now a disease that can be treated and in most cases, it is possible to extend survival times with good quality of life. Antineoplastic treatment is usually a combination of multiple therapeutic modalities, in which surgery plays an important role for diagnosis and local control of the disease. Chemotherapy, and most recently immunotherapy, help in the systemic control of the remaining disease. Other modalities such as electrochemotherapy, radiotherapy and cryosurgery can also help in the management of cancer patients. In Mexico, oncology is still a novel medical specialty, but one in constant development.

show abstract

Epidemiological study of canine transmissible venereal tumor (CTVT) in Brazil, 2000–2020

Pimentel

Oliveira

Horta

2021

Preventive Veterinary Medicine

View full text Add to dashboard Cite

Treatment of canine transmissible venereal tumor using L-asparaginase, prednisone, and surgery in a clinical chemotherapy-resistant case

Cited by 6 publications

References 9 publications

Lomustine therapy for vincristine-resistant canine transmissible venereal tumor: a case report

Lomustine therapy for vincristine-resistant canine transmissible venereal tumor: a case report

Estrategias terapéuticas contra el cáncer en animales de compañía

Epidemiological study of canine transmissible venereal tumor (CTVT) in Brazil, 2000–2020

Contact Info

Product

Resources

About