Treatment of Carcinoid Syndrome with Recombinant Interferon Alpha-2a

Bartolomeo, Maria Di; Bajetta, Emilio; Zilembo, Nicoletta; Braud, Filippo de; Leo, Angelo Di; Verusio, Claudio; D'Aprile, M; Scanni, A.; Iirillo, A.; Barduagni, Aldo; Epifani, C.

doi:10.3109/02841869309083918

Cited by 33 publications

(12 citation statements)

References 13 publications

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“…6 The efficacy of interferon-α, -γ, or somatostatin analogue has been suggested in cases with liver metastasis of gastrointestinal carcinoid tumor. 10,[17][18][19] Systemic administrations of anticancer chemotherapeutic agents were often attempted to treat metastatic disease arising from carcinoid tumors. 20 The transarterial administration of these agents and/or embolization was reported to be a useful therapeutic strategy for liver metastasis of carcinoid tumors because they were often accompanied by an enhanced tumor vasculature.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

et al. 2004

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Carcinoid tumors are known to occur frequently in the gastrointestinal tract and they can develop in nearly every organ system. However, a carcinoid tumor of the kidney is an extremely rare entity and only 38 cases have been reported in the English literature. We herein describe the 39th case of primary renal carcinoid tumor, found in a young Japanese woman 2 months after delivery. The pathologic similarities of our case with those of previously reported cases are briefly reviewed together with some aspects of clinical features and prognostic factors of this rare disease.

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Section: Discussionmentioning

confidence: 99%

Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

et al. 2004

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“…Early recognition of the neuroendocrine differentiation is very important, because NETs have a low mitotic index and could, in some cases, have a favorable prognosis. Furthermore, early identification of NETs would allow a more efficient control of the syndromes and the proliferative activity of the tumor (e.g., by a timely administration of interferons or somatostatin analogs) 30, 42, 43…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the need for specific biomarkers also is related to the evaluation of response to treatment. In fact, in patients with NETs, one of the parameters to be considered in clinical assessment is represented by any reductions in the circulating levels of tumor‐released substances 26–31…”

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confidence: 99%

Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors

Bajetta

Ferrari

Martinetti

et al. 1999

Cancer

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BACKGROUND Chromogranin A (CgA), neuron specific enolase (NSE), carcinoembryonic antigen (CEA), and urinary 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) are the markers currently used in the diagnosis, prognosis, and follow‐up of patients with neuroendocrine tumors (NETs). The authors examined the role of such biomarkers in a large series of patients with NETs. METHODS One hundred and twenty‐seven patients entered the study. Multiple blood and 24‐hour urine specimens were assayed for biomarker quantitation. RESULTS The accuracy of each marker was assessed in patients with (n = 106) and without (n = 21) disease. CgA proved to be the best marker (specificity of 85.7% and sensitivity of 67.9%). Patients with disease had significantly higher CgA and NSE levels compared with disease free patients (P = 0.00003 and P = 0.00240, respectively). NSE and 5‐HIAA determination showed a very high specificity (100%) but a rather low sensitivity (32.9% and 35.1%, respectively). CEA was found to have little diagnostic value (sensitivity of 15.4%). CgA was the most sensitive marker for detecting patients with disseminated disease and 5‐HIAA displayed the highest sensitivity in identifying syndromic patients. Tumor marker modifications were studied during follow‐up. In particular, rises in CgA were associated with progressive disease in 83.3% of cases and stable CgA was associated with stable disease in 53.8% of cases. The relation between CgA modifications and liver lesions during follow‐up also was studied; increases in CgA levels were associated with local progression in 100% of cases and stable marker levels were found in 68.7% of the patients with unchanged lesions. CONCLUSIONS The results of the current study demonstrate that CgA has the highest accuracy and is the most reliable biomarker reflecting the clinical evolution of NETs. Cancer 1999;86:858–65. © 1999 American Cancer Society.

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“… 1 Though the effect of interferon on renal carcinoid has not been established, some authors have reported its effectiveness on carcinoid tumor. 14–16 Our patient had lymph node metastasis at the time of operation, but has had no evidence of local recurrence or distant metastasis for 3 years after surgery with subsequent interferon therapy. Even with any metastasis, surgical removal of primary and metastatic lesions may be beneficial especially in the treatment of renal carcinoid within the horseshoe kidney.…”

Section: Discussionmentioning

confidence: 99%

Primary carcinoid tumor in a horseshoe kidney

et al. 2000

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A case of primary carcinoid tumor arising within a horseshoe kidney in a 51-year-old woman is reported. The tumor was found incidentally by computed tomography (CT) during a check-up for a suspected gall bladder polyp. Histologic, immunohistochemical and electron microscopic analyses of this tumor revealed features typical of carcinoid tumor. Primary carcinoid tumor of the kidney is extremely rare and only 32 cases were previously reported, including five cases in horseshoe kidneys. None of these five cases in horseshoe kidneys demonstrated any evidence of local or distant metastases and all were alive at the time of reporting without evidence of disease after up to 3 years of follow up. The present case, even with accompanying lymph nodal metastasis, also has had no evidence of local recurrence or distant metastasis for 3 years post operation. Primary carcinoid tumor arising within horseshoe kidneys appear to be more benign than those within nonhorseshoe kidneys.

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Treatment of Carcinoid Syndrome with Recombinant Interferon Alpha-2a

Cited by 33 publications

References 13 publications

Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors

Primary carcinoid tumor in a horseshoe kidney

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