Treatment of Cardiac Hemochromatosis

Aronow, Wilbert S.

doi:10.17140/hroj-2-e002

Heart Res Open J

2015

DOI: 10.17140/hroj-2-e002

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Treatment of Cardiac Hemochromatosis

Wilbert S. Aronow¹

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2024

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Cited by 1 publication

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Cardiac Manifestations of Hemochromatosis

Gera,

Oliveira,

Frishman

et al. 2024

Cardiology in Review

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Cardiac hemochromatosis, a consequence of primary or secondary iron-overload conditions, poses a threat to patient health, leading to cardiomyopathy and heart failure. This review aims to compile comprehensive information on cardiac hemochromatosis, elucidating its pathophysiology, clinical presentation, diagnosis, and management strategies. Primary and secondary hemochromatosis, genetic and acquired forms, can result in cardiotoxicity by means of iron dysregulation. Diagnostic tools, including biochemical markers, electrocardiography, echocardiography, and magnetic resonance imaging (MRI), are utilized for early detection as well as long-term monitoring post-treatment. For treatment options, phlebotomy is the standard, but for some patients (such as those with anemia), chelation therapy is an alternative option. Other potential therapies include erythrocytapheresis, calcium channel blockers, and hepcidin-targeted approaches, for which more research is needed to understand cardiac function benefits. With the onset of cardiac symptoms, patient health rapidly deteriorates. Thus, timely intervention to mitigate associated morbidity and mortality by means of screening can promote and prolong patient survival.

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Cardiac Manifestations of Hemochromatosis

Gera,

Oliveira,

Frishman

et al. 2024

Cardiology in Review

View full text Add to dashboard Cite

show abstract

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Treatment of Cardiac Hemochromatosis

Cited by 1 publication

References 21 publications

Cardiac Manifestations of Hemochromatosis

Cardiac Manifestations of Hemochromatosis

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