Treatment of cerebrospinal nematodiasis in a Boer Buck

Breuer, Ryan; Merkatoris, Paul; Tepley, Samantha; Dierks, Caitlyn; Klostermann, Cassandra A.; Flaherty, Heather A.; Smith, Joe S.

doi:10.1136/vetreccr-2018-000706

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…23 Transitioning from 1 NSAID to another can potentially lead to complications, however there are several cases of ruminants being initially treated with a single dose of flunixin and then being transitioned to meloxicam without adverse effects. 24,25 Heifers in our case study did not demonstrate any evidence of abomasal ulceration and postoperatively were maintained on oral meloxicam (1 mg/kg) once daily for 5 days. Treatment with NSAIDs (ketoprofen or meloxicam) in dairy cows after flank laparotomy (rumen fistula placement) improved outcomes of pain with no difference between them.…”

Section: Discussionmentioning

confidence: 62%

Electrosurgical bipolar vessel sealing for a standing flank ovariectomy in beef heifers

Smith¹,

Salazar²,

Peace³

et al. 2021

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Traditional ovariectomy techniques for heifers (e.g. colpotomy) have adverse effects rangingfrom hemorrhage to mortality. Electrosurgical bipolar vessel sealing devices offer a superior ligation ofovarian pedicle and associated structures. In ruminants, standing flank laparotomy has been used forabdominal visibility. We performed ovariectomy in 2 companion beef heifers via a unilateral flankapproach, combined with electrosurgical ligation. Surgeries were performed in standing animals, underlocal anesthesia, with no observed short- or long-term adverse effects. This technique is worthconsidering for cases where the security of electrosurgical ligation combined with the accessibility of aflank laparotomy are desired. Additional research is needed to determine the viability of the technique forcattle of various ages and breeds.

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Section: Discussionmentioning

confidence: 62%

Electrosurgical bipolar vessel sealing for a standing flank ovariectomy in beef heifers

Smith¹,

Salazar²,

Peace³

et al. 2021

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“…While concern exists with increased potential adverse effects when multiple nonsteroidal anti-inflammatory drugs are administered to the same patient, flunixin was administered for a short time period, followed by meloxicam to limit overlap. Additionally, cases of initiating treatment with flunixin and then converting to meloxicam are reported without adverse effect in the caprine literature [ 20 ]. Withdrawal advice was obtained from the Food Animal Residue Avoidance Databank and communicated to the client at discharge.…”

Section: Discussionmentioning

confidence: 99%

Delayed Urethral Obstruction after Migration of a Ballistic Pellet in an Alpine Wether

Smith,

Hespel,

Garcia

et al. 2023

Case Reports in Veterinary Medicine

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A one-year-old alpine wether was presented for emergency evaluation of stranguria. Diagnostics identified a moderately distended bladder and mild dehydration. Preliminary lateral radiographs identified two metallic structures consistent with projectile pellets in the pelvic and perineal regions and no evidence of radiopaque uroliths. A tube cystostomy was performed, and a contrast urethrogram revealed one of the pellets in the perineal region was in proximity to the urethral obstruction. Subsequent radiography and ultrasound identified the pellet as being within the lumen of the urethra. Examination of the trichotomized skin revealed two scars, including a scar over the paralumbar fossa in the region of the urinary bladder suggestive of a projectile injury. The pellet was removed by a perineal urethrotomy. The patient was able to spontaneously urinate after urethrotomy, passed a tube cystostomy challenge two weeks after surgery, and was discharged. No complications were reported. While uncommon in the veterinary and comparative medical literature, clinicians should consider the potential for projectile pellets to migrate into the urinary tract after initial injury.

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“…Historical reports describe prednisolone for chemotherapy of lymphosarcoma or lymphoma (23,24). Anti-inflammatory doses are used for management of soft tissue injury from causes such as cerebrospinal nematodiasis and rattlesnake envenomation (25)(26)(27). Additional descriptions exist for the treatment of certain dermatological conditions (28).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Orally Administered Prednisolone in Alpacas

et al. 2021

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This study aimed to determine the pharmacokinetics of prednisolone following intravenous and oral administration in healthy adult alpacas. Healthy adult alpacas were given prednisolone (IV, n = 4), as well as orally (PO, n = 6). Prednisolone was administered IV once (1 mg/kg). Oral administration was once daily for 5 days (2 mg/kg). Each treatment was separated by a minimum 4 month washout period. Samples were collected at 0 (pre-administration), 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, and 24 h after IV administration, and at 0 (pre-administration), 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, 24 after the first and 5th PO administration. Samples were also taken for serial complete blood count and biochemistry analysis. Prednisolone concentration was determined by high pressure liquid chromatography. Non-compartmental pharmacokinetic parameters were then determined. After IV administration clearance was 347 mL/kg/hr, elimination half-life was 2.98 h, and area under the curve was 2,940 h*ng/mL. After initial and fifth oral administration elimination half-life was 5.27 and 5.39 h; maximum concentration was 74 and 68 ng/mL; time to maximum concentration was 2.67 and 2.33 h; and area under the curve was 713 and 660 hr*ng/mL. Oral bioavailability was determined to be 13.7%. Packed cell volume, hemoglobin, and red blood cell counts were significantly decreased 5 days after the first PO administration, and serum glucose was significantly elevated 5 days after the first PO administration. In conclusion, serum concentrations of prednisolone after IV and PO administration appear to be similar to other veterinary species. Future research will be needed to determine the pharmacodynamics of prednisolone in alpacas.

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Treatment of cerebrospinal nematodiasis in a Boer Buck

Cited by 5 publications

References 10 publications

Electrosurgical bipolar vessel sealing for a standing flank ovariectomy in beef heifers

Electrosurgical bipolar vessel sealing for a standing flank ovariectomy in beef heifers

Delayed Urethral Obstruction after Migration of a Ballistic Pellet in an Alpine Wether

Pharmacokinetics of Orally Administered Prednisolone in Alpacas

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